Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics.
<h4>Objective</h4>To investigate the role of quercetin-added pancreatic prescription food in regulating metabolic homeostasis in dogs.<h4>Methods</h4>The experimental dogs were divided into a control diet group and a prescription diet group. The control group was fed regular...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0318159 |
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| author | Xiao-Wan Liu Yao-Hui Zhang Li Xu Jia-Bao Xing Zhou-Xiang Wang Man-Li Hu Yun Chen Zhi-Li Qi Yi Ding Xin Zhang Ming-Xing Ding Xiao-Jing Zhang Juan Wan |
| author_facet | Xiao-Wan Liu Yao-Hui Zhang Li Xu Jia-Bao Xing Zhou-Xiang Wang Man-Li Hu Yun Chen Zhi-Li Qi Yi Ding Xin Zhang Ming-Xing Ding Xiao-Jing Zhang Juan Wan |
| author_sort | Xiao-Wan Liu |
| collection | DOAJ |
| description | <h4>Objective</h4>To investigate the role of quercetin-added pancreatic prescription food in regulating metabolic homeostasis in dogs.<h4>Methods</h4>The experimental dogs were divided into a control diet group and a prescription diet group. The control group was fed regular food, while the prescription group was fed pancreatic prescription food (3.9 g of quercetin was added in per 1 kg of food) for 8 weeks. Canine physical examination, complete blood count, and serum biochemical tests were conducted at 0 w, 4 w, and 8 w. Non-targeted metabolomics tests were performed using plasma samples at 0 w and 8 w.<h4>Results</h4>Dogs that received a quercetin-added pancreatic diet supplemented with quercetin showed no changes in the body weight, fasting blood glucose, body condition score, the indexes of whole blood program of red blood cells, white blood cells and platelets, and most blood biochemical indexes, but increased lipase levels in plasma at 8 w. Quercetin significant improved in metabolic homeostasis, especially in fatty acid, amino acid, and bile acid metabolism. Untargeted metabolomics analysis revealed that quercetin activates ABC transport and arginine/proline pathways, suggesting potential benefits for pancreatitis in large animals, while maintaining comparable safety parameters.<h4>Conclusions</h4>Quercetin-added prescription food enhances fatty acid and amino acid metabolism, demonstrating its potential to promote pancreatic function and sustain metabolic homeostasis. |
| format | Article |
| id | doaj-art-898be2ee2b8a47f99ce9e7a4d5f74586 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-898be2ee2b8a47f99ce9e7a4d5f745862025-08-20T02:28:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031815910.1371/journal.pone.0318159Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics.Xiao-Wan LiuYao-Hui ZhangLi XuJia-Bao XingZhou-Xiang WangMan-Li HuYun ChenZhi-Li QiYi DingXin ZhangMing-Xing DingXiao-Jing ZhangJuan Wan<h4>Objective</h4>To investigate the role of quercetin-added pancreatic prescription food in regulating metabolic homeostasis in dogs.<h4>Methods</h4>The experimental dogs were divided into a control diet group and a prescription diet group. The control group was fed regular food, while the prescription group was fed pancreatic prescription food (3.9 g of quercetin was added in per 1 kg of food) for 8 weeks. Canine physical examination, complete blood count, and serum biochemical tests were conducted at 0 w, 4 w, and 8 w. Non-targeted metabolomics tests were performed using plasma samples at 0 w and 8 w.<h4>Results</h4>Dogs that received a quercetin-added pancreatic diet supplemented with quercetin showed no changes in the body weight, fasting blood glucose, body condition score, the indexes of whole blood program of red blood cells, white blood cells and platelets, and most blood biochemical indexes, but increased lipase levels in plasma at 8 w. Quercetin significant improved in metabolic homeostasis, especially in fatty acid, amino acid, and bile acid metabolism. Untargeted metabolomics analysis revealed that quercetin activates ABC transport and arginine/proline pathways, suggesting potential benefits for pancreatitis in large animals, while maintaining comparable safety parameters.<h4>Conclusions</h4>Quercetin-added prescription food enhances fatty acid and amino acid metabolism, demonstrating its potential to promote pancreatic function and sustain metabolic homeostasis.https://doi.org/10.1371/journal.pone.0318159 |
| spellingShingle | Xiao-Wan Liu Yao-Hui Zhang Li Xu Jia-Bao Xing Zhou-Xiang Wang Man-Li Hu Yun Chen Zhi-Li Qi Yi Ding Xin Zhang Ming-Xing Ding Xiao-Jing Zhang Juan Wan Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics. PLoS ONE |
| title | Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics. |
| title_full | Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics. |
| title_fullStr | Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics. |
| title_full_unstemmed | Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics. |
| title_short | Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via metabolomics. |
| title_sort | exploring the effects of quercetin added pancreatic diet on metabolic homeostasis in dogs via metabolomics |
| url | https://doi.org/10.1371/journal.pone.0318159 |
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