miRNAs Participate in MS Pathological Processes and Its Therapeutic Response
Multiple sclerosis is the most common autoimmune disease of the central nervous system. It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. In this review, we discuss microRNAs participat...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4578230 |
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| _version_ | 1832550152083079168 |
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| author | Ting Wu Guangjie Chen |
| author_facet | Ting Wu Guangjie Chen |
| author_sort | Ting Wu |
| collection | DOAJ |
| description | Multiple sclerosis is the most common autoimmune disease of the central nervous system. It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. In this review, we discuss microRNAs participating in the pathological processes of MS, including periphery inflammation, blood-brain barrier disruption, and CNS lesions, and in its therapeutic response, in order to find biomarkers of disease severity and to predict the response to therapy of the diseases. |
| format | Article |
| id | doaj-art-898aab7836164c488cf6a2a74ac3f89b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-898aab7836164c488cf6a2a74ac3f89b2025-02-03T06:07:29ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/45782304578230miRNAs Participate in MS Pathological Processes and Its Therapeutic ResponseTing Wu0Guangjie Chen1Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, ChinaDepartment of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, ChinaMultiple sclerosis is the most common autoimmune disease of the central nervous system. It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. In this review, we discuss microRNAs participating in the pathological processes of MS, including periphery inflammation, blood-brain barrier disruption, and CNS lesions, and in its therapeutic response, in order to find biomarkers of disease severity and to predict the response to therapy of the diseases.http://dx.doi.org/10.1155/2016/4578230 |
| spellingShingle | Ting Wu Guangjie Chen miRNAs Participate in MS Pathological Processes and Its Therapeutic Response Mediators of Inflammation |
| title | miRNAs Participate in MS Pathological Processes and Its Therapeutic Response |
| title_full | miRNAs Participate in MS Pathological Processes and Its Therapeutic Response |
| title_fullStr | miRNAs Participate in MS Pathological Processes and Its Therapeutic Response |
| title_full_unstemmed | miRNAs Participate in MS Pathological Processes and Its Therapeutic Response |
| title_short | miRNAs Participate in MS Pathological Processes and Its Therapeutic Response |
| title_sort | mirnas participate in ms pathological processes and its therapeutic response |
| url | http://dx.doi.org/10.1155/2016/4578230 |
| work_keys_str_mv | AT tingwu mirnasparticipateinmspathologicalprocessesanditstherapeuticresponse AT guangjiechen mirnasparticipateinmspathologicalprocessesanditstherapeuticresponse |