Advances in growth factor-containing 3D printed scaffolds in orthopedics

Abstract Currently, bone tissue engineering is a research hotspot in the treatment of orthopedic diseases, and many problems in orthopedics can be solved through bone tissue engineering, which can be used to treat fractures, bone defects, arthritis, etc. More importantly, it can provide an alternati...

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Main Authors: Longwen Zhan, Yigui Zhou, Ruitang Liu, Ruilong Sun, Yunfei Li, Yongzheng Tian, Bo Fan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BioMedical Engineering OnLine
Subjects:
Online Access:https://doi.org/10.1186/s12938-025-01346-z
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author Longwen Zhan
Yigui Zhou
Ruitang Liu
Ruilong Sun
Yunfei Li
Yongzheng Tian
Bo Fan
author_facet Longwen Zhan
Yigui Zhou
Ruitang Liu
Ruilong Sun
Yunfei Li
Yongzheng Tian
Bo Fan
author_sort Longwen Zhan
collection DOAJ
description Abstract Currently, bone tissue engineering is a research hotspot in the treatment of orthopedic diseases, and many problems in orthopedics can be solved through bone tissue engineering, which can be used to treat fractures, bone defects, arthritis, etc. More importantly, it can provide an alternative to traditional bone grafting and solve the problems of insufficient autologous bone grafting, poor histocompatibility of grafts, and insufficient induced bone regeneration. Growth factors are key factors in bone tissue engineering by promoting osteoblast proliferation and differentiation, which in turn increases the efficiency of osteogenesis and bone regeneration. 3D printing technology can provide carriers with better pore structure for growth factors to improve the stability of growth factors and precisely control their release. Studies have shown that 3D-printed scaffolds containing growth factors provide a better choice for personalized treatment, bone defect repair, and bone regeneration in orthopedics, which are important for the treatment of orthopedic diseases and have potential research value in orthopedic applications. This paper aims to summarize the research progress of 3D printed scaffolds containing growth factors in orthopedics in recent years and summarize the use of different growth factors in 3D scaffolds, including bone morphogenetic proteins, platelet-derived growth factors, transforming growth factors, vascular endothelial growth factors, etc. Optimization of material selection and the way of combining growth factors with scaffolds are also discussed.
format Article
id doaj-art-898939b9b7104527ab78f509da609714
institution Kabale University
issn 1475-925X
language English
publishDate 2025-02-01
publisher BMC
record_format Article
series BioMedical Engineering OnLine
spelling doaj-art-898939b9b7104527ab78f509da6097142025-02-09T12:47:30ZengBMCBioMedical Engineering OnLine1475-925X2025-02-0124112310.1186/s12938-025-01346-zAdvances in growth factor-containing 3D printed scaffolds in orthopedicsLongwen Zhan0Yigui Zhou1Ruitang Liu2Ruilong Sun3Yunfei Li4Yongzheng Tian5Bo Fan6Orthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyOrthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyOrthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyOrthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyOrthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyOrthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyOrthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyAbstract Currently, bone tissue engineering is a research hotspot in the treatment of orthopedic diseases, and many problems in orthopedics can be solved through bone tissue engineering, which can be used to treat fractures, bone defects, arthritis, etc. More importantly, it can provide an alternative to traditional bone grafting and solve the problems of insufficient autologous bone grafting, poor histocompatibility of grafts, and insufficient induced bone regeneration. Growth factors are key factors in bone tissue engineering by promoting osteoblast proliferation and differentiation, which in turn increases the efficiency of osteogenesis and bone regeneration. 3D printing technology can provide carriers with better pore structure for growth factors to improve the stability of growth factors and precisely control their release. Studies have shown that 3D-printed scaffolds containing growth factors provide a better choice for personalized treatment, bone defect repair, and bone regeneration in orthopedics, which are important for the treatment of orthopedic diseases and have potential research value in orthopedic applications. This paper aims to summarize the research progress of 3D printed scaffolds containing growth factors in orthopedics in recent years and summarize the use of different growth factors in 3D scaffolds, including bone morphogenetic proteins, platelet-derived growth factors, transforming growth factors, vascular endothelial growth factors, etc. Optimization of material selection and the way of combining growth factors with scaffolds are also discussed.https://doi.org/10.1186/s12938-025-01346-z3D printingGrowth factorsScaffoldsBone regeneration
spellingShingle Longwen Zhan
Yigui Zhou
Ruitang Liu
Ruilong Sun
Yunfei Li
Yongzheng Tian
Bo Fan
Advances in growth factor-containing 3D printed scaffolds in orthopedics
BioMedical Engineering OnLine
3D printing
Growth factors
Scaffolds
Bone regeneration
title Advances in growth factor-containing 3D printed scaffolds in orthopedics
title_full Advances in growth factor-containing 3D printed scaffolds in orthopedics
title_fullStr Advances in growth factor-containing 3D printed scaffolds in orthopedics
title_full_unstemmed Advances in growth factor-containing 3D printed scaffolds in orthopedics
title_short Advances in growth factor-containing 3D printed scaffolds in orthopedics
title_sort advances in growth factor containing 3d printed scaffolds in orthopedics
topic 3D printing
Growth factors
Scaffolds
Bone regeneration
url https://doi.org/10.1186/s12938-025-01346-z
work_keys_str_mv AT longwenzhan advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics
AT yiguizhou advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics
AT ruitangliu advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics
AT ruilongsun advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics
AT yunfeili advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics
AT yongzhengtian advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics
AT bofan advancesingrowthfactorcontaining3dprintedscaffoldsinorthopedics