Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control

BACKGROUND: Amantadine, an antiviral agent, is the only drug currently approved in Canada for prophylaxis of influenza A virus infection. To minimize side effects, the amantadine dose is adjusted for age and estimated creatinine clearance (CrCl) based on plasma creatinine (Cr) levels. As amantadine...

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Main Authors: Jane A Buxton, Danuta M Skowronski, Helen Ng, Steve A Marion, Michele Williams, Anna Forbes, Arlene King, Jamie Hockin
Format: Article
Language:English
Published: Wiley 2001-01-01
Series:Canadian Journal of Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2001/926732
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author Jane A Buxton
Danuta M Skowronski
Helen Ng
Steve A Marion
Michele Williams
Anna Forbes
Arlene King
Jamie Hockin
author_facet Jane A Buxton
Danuta M Skowronski
Helen Ng
Steve A Marion
Michele Williams
Anna Forbes
Arlene King
Jamie Hockin
author_sort Jane A Buxton
collection DOAJ
description BACKGROUND: Amantadine, an antiviral agent, is the only drug currently approved in Canada for prophylaxis of influenza A virus infection. To minimize side effects, the amantadine dose is adjusted for age and estimated creatinine clearance (CrCl) based on plasma creatinine (Cr) levels. As amantadine is used more frequently for influenza A outbreak control in care facilities for elderly people, physicians are increasingly called on to prescribe it for residents and to consider the necessity of requesting plasma Cr levels.
format Article
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issn 1180-2332
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publishDate 2001-01-01
publisher Wiley
record_format Article
series Canadian Journal of Infectious Diseases
spelling doaj-art-89885459052b4145ae6cec12db3e28652025-08-20T02:09:38ZengWileyCanadian Journal of Infectious Diseases1180-23322001-01-0112528528810.1155/2001/926732Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak ControlJane A Buxton0Danuta M Skowronski1Helen Ng2Steve A Marion3Michele Williams4Anna Forbes5Arlene King6Jamie Hockin7British Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaDepartment of Health Care and Epidemiology, University of British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaConsultant Geriatrician, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaField Epidemiology Training Program, Laboratory Centre for Disease Control, Health Canada, Ottawa, CanadaBACKGROUND: Amantadine, an antiviral agent, is the only drug currently approved in Canada for prophylaxis of influenza A virus infection. To minimize side effects, the amantadine dose is adjusted for age and estimated creatinine clearance (CrCl) based on plasma creatinine (Cr) levels. As amantadine is used more frequently for influenza A outbreak control in care facilities for elderly people, physicians are increasingly called on to prescribe it for residents and to consider the necessity of requesting plasma Cr levels.http://dx.doi.org/10.1155/2001/926732
spellingShingle Jane A Buxton
Danuta M Skowronski
Helen Ng
Steve A Marion
Michele Williams
Anna Forbes
Arlene King
Jamie Hockin
Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control
Canadian Journal of Infectious Diseases
title Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control
title_full Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control
title_fullStr Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control
title_full_unstemmed Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control
title_short Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control
title_sort previous creatinine levels safely predict amantadine dose for influenza a outbreak control
url http://dx.doi.org/10.1155/2001/926732
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