ANXA2 regulates mitochondrial function and cellular senescence of PDLCs via AKT/eNOS signaling pathway under high glucose conditions

ANXA2 regulates mitochondrial function and cellular senescence of PDLCs via AKT/eNOS signaling pathway under high glucose conditions

Abstract Diabetes mellitus is one of the risk factors for periodontitis. Patients with diabetes mellitus possess higher prevalence of periodontitis, more severe periodontal destruction, yet the underlying mechanisms of action are not yet clear. Annexin A2 (ANXA2) is a calcium-dependent phospholipid-...

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Bibliographic Details
Main Authors: Yanlin Huang, Zejing Qiu, Chunhui Jiang, Qian Fang, Jiaye Wang, Mingfang Han, Yizhao Liu, Zehui Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Mitochondria
Cellular senescence
Mitophagy
Diabetes
Periodontitis
Online Access:https://doi.org/10.1038/s41598-025-00950-2
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