Linezolid-Induced Myelosuppression
Linezolid is an antibiotic effective against resistant gram-positive bacteria. While side effects are typically mild, myelosuppression can occur, with pancytopenia being a rare but serious condition. We report on a 94-year-old woman who developed pancytopenia following linezolid treatment of celluli...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-08-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0263 |
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| _version_ | 1850198166096314368 |
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| author | Kristiana Jordan Kristen D. Kelley |
| author_facet | Kristiana Jordan Kristen D. Kelley |
| author_sort | Kristiana Jordan |
| collection | DOAJ |
| description | Linezolid is an antibiotic effective against resistant gram-positive bacteria. While side effects are typically mild, myelosuppression can occur, with pancytopenia being a rare but serious condition. We report on a 94-year-old woman who developed pancytopenia following linezolid treatment of cellulitis and myositis. Despite initial stability, her condition necessitated rehospitalization. Hematologic recovery ensued after linezolid was discontinued. This case highlights the need for awareness of linezolid-induced myelosuppression, especially with risk factors like advanced age and sodium–glucose cotransporter-2 inhibitor use. Clinicians should monitor for hematologic adverse effects of linezolid, especially in patients with associated risk profiles. |
| format | Article |
| id | doaj-art-897bb69b719a46639a2f5ebc1f90bcf0 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-897bb69b719a46639a2f5ebc1f90bcf02025-08-20T02:12:57ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-08-013810.7326/aimcc.2024.0263Linezolid-Induced MyelosuppressionKristiana Jordan0Kristen D. Kelley11The University of California Davis School of Medicine, Sacramento, California2Division of General Internal Medicine, Department of Internal Medicine University of California Davis, Sacramento, CaliforniaLinezolid is an antibiotic effective against resistant gram-positive bacteria. While side effects are typically mild, myelosuppression can occur, with pancytopenia being a rare but serious condition. We report on a 94-year-old woman who developed pancytopenia following linezolid treatment of cellulitis and myositis. Despite initial stability, her condition necessitated rehospitalization. Hematologic recovery ensued after linezolid was discontinued. This case highlights the need for awareness of linezolid-induced myelosuppression, especially with risk factors like advanced age and sodium–glucose cotransporter-2 inhibitor use. Clinicians should monitor for hematologic adverse effects of linezolid, especially in patients with associated risk profiles.https://www.acpjournals.org/doi/10.7326/aimcc.2024.0263 |
| spellingShingle | Kristiana Jordan Kristen D. Kelley Linezolid-Induced Myelosuppression Annals of Internal Medicine: Clinical Cases |
| title | Linezolid-Induced Myelosuppression |
| title_full | Linezolid-Induced Myelosuppression |
| title_fullStr | Linezolid-Induced Myelosuppression |
| title_full_unstemmed | Linezolid-Induced Myelosuppression |
| title_short | Linezolid-Induced Myelosuppression |
| title_sort | linezolid induced myelosuppression |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0263 |
| work_keys_str_mv | AT kristianajordan linezolidinducedmyelosuppression AT kristendkelley linezolidinducedmyelosuppression |