A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study
Background: Leptomeningeal carcinomatosis involves the diffuse infiltration of neoplastic cells in the central nervous system, affecting 5-8% of leukemia, breast, and lung cancer cases. Gastric cancer instances are rare, mostly in poorly differentiated adenocarcinomas. We report the first Peruvian c...
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| Language: | English |
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Babol University of Medical Sciences
2025-03-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-4203-en.pdf |
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| author | Juan Eduardo Quiroz-Aldave María del Carmen Durand-Vásquez Ramiro Herrera Cabezas Rossana Jimenez Asto Carlos Cerrón Aguilar Julia Cristina Coronado-Arroyo Francisca Zavaleta-Gutiérrez Luis Alberto Concepción-Urteaga Benjamín Alberto Leiva Marcio José Concepción-Zavaleta |
| author_facet | Juan Eduardo Quiroz-Aldave María del Carmen Durand-Vásquez Ramiro Herrera Cabezas Rossana Jimenez Asto Carlos Cerrón Aguilar Julia Cristina Coronado-Arroyo Francisca Zavaleta-Gutiérrez Luis Alberto Concepción-Urteaga Benjamín Alberto Leiva Marcio José Concepción-Zavaleta |
| author_sort | Juan Eduardo Quiroz-Aldave |
| collection | DOAJ |
| description | Background: Leptomeningeal carcinomatosis involves the diffuse infiltration of neoplastic cells in the central nervous system, affecting 5-8% of leukemia, breast, and lung cancer cases. Gastric cancer instances are rare, mostly in poorly differentiated adenocarcinomas. We report the first Peruvian case, featuring gastric adenocarcinoma.
Case Presentation: A 51-year-old woman presented with severe headache, vomiting, dizziness, blurred vision, tinnitus, bradyphrenia, reduced verbal fluency, sixth cranial nerve paresis, and non-reactive anisocoric pupils. Pleocytosis was found, with positive cytology for metastatic adenocarcinoma in cerebrospinal fluid, and a solid gastric mass defined as poorly differentiated adenocarcinoma. Due to her condition, the patient did not receive oncological management, evolving unfavorably and passing away twenty days later.
Discussion: Leptomeningeal carcinomatosis should be considered in patients with advanced cancer and meningeal symptoms. It is more predominant in women, with an average age of 53.84 years. Clinical presentation of leptomeningeal carcinomatosis varies, and diagnosis involves neuroimaging and cerebrospinal fluid cytology. Prognosis is unfavorable, often leading to fatality. Treatment protocols lack standardization, and personalized approaches, including targeted and systemic therapies, are explored for improved outcomes. The exceptional aspect of our case lies in the unique diagnosis of an abdominal tumor following the manifestation of neurological symptoms.
Conclusion: It is important to suspect this condition among the causes of meningitis, especially in the presence of an underlying malignancy. |
| format | Article |
| id | doaj-art-897b887c7c964cb0831edabfbc421e4f |
| institution | OA Journals |
| issn | 2008-6164 2008-6172 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj-art-897b887c7c964cb0831edabfbc421e4f2025-08-20T01:52:48ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722025-03-01162369374A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case studyJuan Eduardo Quiroz-Aldave0María del Carmen Durand-Vásquez1Ramiro Herrera Cabezas2Rossana Jimenez Asto3Carlos Cerrón Aguilar4Julia Cristina Coronado-Arroyo5Francisca Zavaleta-Gutiérrez6Luis Alberto Concepción-Urteaga7Benjamín Alberto Leiva8Marcio José Concepción-Zavaleta9 Division of Medicine, Hospital de Apoyo Chepén. Chepén, Perú Division of Family Medicine, Hospital de Apoyo Chepén. Chepén, Perú Division of Internal Medicine, Hospital Nacional Guillermo Almenara Irigoyen. Lima, Perú School of Medicine “Manuel Huamán Guerrero”, Universidad Ricardo Palma, Lima, Perú Division of Internal Medicine, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú Clínica Internacional, Lima, Perú Division of Neonatology, Hospital Belén de Trujillo, Trujillo, Perú Division of Internal Medicine, Hospital Regional Docente de Trujillo, Trujillo, Perú Division of Surgical Oncology, Hospital Eleazar Guzmán Barrón. Nuevo Chimbote, Perú Universidad Científica del Sur, Lima, Perú Background: Leptomeningeal carcinomatosis involves the diffuse infiltration of neoplastic cells in the central nervous system, affecting 5-8% of leukemia, breast, and lung cancer cases. Gastric cancer instances are rare, mostly in poorly differentiated adenocarcinomas. We report the first Peruvian case, featuring gastric adenocarcinoma. Case Presentation: A 51-year-old woman presented with severe headache, vomiting, dizziness, blurred vision, tinnitus, bradyphrenia, reduced verbal fluency, sixth cranial nerve paresis, and non-reactive anisocoric pupils. Pleocytosis was found, with positive cytology for metastatic adenocarcinoma in cerebrospinal fluid, and a solid gastric mass defined as poorly differentiated adenocarcinoma. Due to her condition, the patient did not receive oncological management, evolving unfavorably and passing away twenty days later. Discussion: Leptomeningeal carcinomatosis should be considered in patients with advanced cancer and meningeal symptoms. It is more predominant in women, with an average age of 53.84 years. Clinical presentation of leptomeningeal carcinomatosis varies, and diagnosis involves neuroimaging and cerebrospinal fluid cytology. Prognosis is unfavorable, often leading to fatality. Treatment protocols lack standardization, and personalized approaches, including targeted and systemic therapies, are explored for improved outcomes. The exceptional aspect of our case lies in the unique diagnosis of an abdominal tumor following the manifestation of neurological symptoms. Conclusion: It is important to suspect this condition among the causes of meningitis, especially in the presence of an underlying malignancy.http://caspjim.com/article-1-4203-en.pdfmeningeal carcinomatosismeningeal neoplasmscerebrospinal fluidgastric cancerneoplasms. |
| spellingShingle | Juan Eduardo Quiroz-Aldave María del Carmen Durand-Vásquez Ramiro Herrera Cabezas Rossana Jimenez Asto Carlos Cerrón Aguilar Julia Cristina Coronado-Arroyo Francisca Zavaleta-Gutiérrez Luis Alberto Concepción-Urteaga Benjamín Alberto Leiva Marcio José Concepción-Zavaleta A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study Caspian Journal of Internal Medicine meningeal carcinomatosis meningeal neoplasms cerebrospinal fluid gastric cancer neoplasms. |
| title | A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study |
| title_full | A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study |
| title_fullStr | A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study |
| title_full_unstemmed | A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study |
| title_short | A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis – A Peruvian case study |
| title_sort | rare neurological odyssey gastric adenocarcinoma and leptomeningeal carcinomatosis a peruvian case study |
| topic | meningeal carcinomatosis meningeal neoplasms cerebrospinal fluid gastric cancer neoplasms. |
| url | http://caspjim.com/article-1-4203-en.pdf |
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