Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications
Molecular imprinting technology (MIT), a synthetic strategy to create tailor-made molecular specificity, has recently achieved significant advancements. Epitope imprinting strategy, an improved MIT by imprinting the epitopes of biomolecules (e.g., proteins and nucleic acids), enables to target the e...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004961 |
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| author | Youlu Diao Jia Gao Yue Ma Guoqing Pan |
| author_facet | Youlu Diao Jia Gao Yue Ma Guoqing Pan |
| author_sort | Youlu Diao |
| collection | DOAJ |
| description | Molecular imprinting technology (MIT), a synthetic strategy to create tailor-made molecular specificity, has recently achieved significant advancements. Epitope imprinting strategy, an improved MIT by imprinting the epitopes of biomolecules (e.g., proteins and nucleic acids), enables to target the entire molecule through recognizing partial epitopes exposed on it, greatly expanding the applicability and simplifying synthesis process of molecularly imprinted polymers (MIPs). Thus, epitope imprinting strategy offers promising solutions for the fabrication of smart biomaterials with molecular targeting and exhibits wide applications in various biomedical scenarios. This review explores the latest advances in epitope imprinting techniques, emphasizing selection of epitopes and functional monomers. We highlight the significant improvements in specificity, sensitivity, and stability of these materials, which have facilitated their use in bioanalysis, clinical therapy, and pharmaceutical development. Additionally, we discuss the application of epitope-imprinted materials in the recognition and detection of peptides, proteins, and cells. Despite these advancements, challenges such as template complexity, imprinting efficiency, and scalability remain. This review addresses these issues and proposes potential directions for future research to overcome these barriers, thereby enhancing the efficacy and practicality of epitope molecularly imprinting technology in biomedical fields. |
| format | Article |
| id | doaj-art-897887cdc14c45628c9a35055bbce409 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-897887cdc14c45628c9a35055bbce4092025-01-26T05:04:21ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145162180Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applicationsYoulu Diao0Jia Gao1Yue Ma2Guoqing Pan3Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013, ChinaInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013, ChinaSchool of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013, China; Corresponding author.Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013, China; Corresponding author.Molecular imprinting technology (MIT), a synthetic strategy to create tailor-made molecular specificity, has recently achieved significant advancements. Epitope imprinting strategy, an improved MIT by imprinting the epitopes of biomolecules (e.g., proteins and nucleic acids), enables to target the entire molecule through recognizing partial epitopes exposed on it, greatly expanding the applicability and simplifying synthesis process of molecularly imprinted polymers (MIPs). Thus, epitope imprinting strategy offers promising solutions for the fabrication of smart biomaterials with molecular targeting and exhibits wide applications in various biomedical scenarios. This review explores the latest advances in epitope imprinting techniques, emphasizing selection of epitopes and functional monomers. We highlight the significant improvements in specificity, sensitivity, and stability of these materials, which have facilitated their use in bioanalysis, clinical therapy, and pharmaceutical development. Additionally, we discuss the application of epitope-imprinted materials in the recognition and detection of peptides, proteins, and cells. Despite these advancements, challenges such as template complexity, imprinting efficiency, and scalability remain. This review addresses these issues and proposes potential directions for future research to overcome these barriers, thereby enhancing the efficacy and practicality of epitope molecularly imprinting technology in biomedical fields.http://www.sciencedirect.com/science/article/pii/S2452199X24004961Epitope imprintingSynthetic antibodyMolecular targetingDrug deliveryCell recognition |
| spellingShingle | Youlu Diao Jia Gao Yue Ma Guoqing Pan Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications Bioactive Materials Epitope imprinting Synthetic antibody Molecular targeting Drug delivery Cell recognition |
| title | Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications |
| title_full | Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications |
| title_fullStr | Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications |
| title_full_unstemmed | Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications |
| title_short | Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications |
| title_sort | epitope imprinted biomaterials with tailor made molecular targeting for biomedical applications |
| topic | Epitope imprinting Synthetic antibody Molecular targeting Drug delivery Cell recognition |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004961 |
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