Risks and Benefits of Helicobacter pylori Eradication: Current Status

In patients with diseases known to be associated with Helicobacter pylori infection, such as peptic ulcer, treatment of the underlying infection is the standard of care. However, in most major consensus management guidelines, including those published in Canada, widespread testing for H pylori infec...

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Main Authors: Richard H Hunt, Carlo Fallone, Sander Veldhuyzen van Zanten, Phil Sherman, Fiona Smaill, Alan BR Thomson, the Canadian Helicobacter Study Group
Format: Article
Language:English
Published: Wiley 2002-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2002/202961
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author Richard H Hunt
Carlo Fallone
Sander Veldhuyzen van Zanten
Phil Sherman
Fiona Smaill
Alan BR Thomson
the Canadian Helicobacter Study Group
author_facet Richard H Hunt
Carlo Fallone
Sander Veldhuyzen van Zanten
Phil Sherman
Fiona Smaill
Alan BR Thomson
the Canadian Helicobacter Study Group
author_sort Richard H Hunt
collection DOAJ
description In patients with diseases known to be associated with Helicobacter pylori infection, such as peptic ulcer, treatment of the underlying infection is the standard of care. However, in most major consensus management guidelines, including those published in Canada, widespread testing for H pylori infection is not recommended. This practice is not encouraged because of insufficient evidence of cost-benefit in gastric cancer prevention, the potential for increases in antibiotic resistance and the controversial hypothesis of potential negative effects of eradication in certain clinical entities. For example, there is insufficient evidence to recommend against eradicating H pylori discovered in a patient with symptoms of gastroesophageal reflux disease. The management guidelines designed specifically in Canada should, therefore, continue to be applied, with H pylori diagnosed and treated in appropriately selected patients.
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spelling doaj-art-8976a55b40b249d7a550b0e9c90ba36c2025-02-03T01:02:28ZengWileyCanadian Journal of Gastroenterology0835-79002002-01-01161576210.1155/2002/202961Risks and Benefits of Helicobacter pylori Eradication: Current StatusRichard H Hunt0Carlo Fallone1Sander Veldhuyzen van Zanten2Phil Sherman3Fiona Smaill4Alan BR Thomson5the Canadian Helicobacter Study GroupDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, McGill University, Montreal, Quebec, CanadaDivision of Gastroenterology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, CanadaDivision of Gastroenterology and Nutrition, Department of Pediatrics, University of Toronto, Toronto, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, CanadaIn patients with diseases known to be associated with Helicobacter pylori infection, such as peptic ulcer, treatment of the underlying infection is the standard of care. However, in most major consensus management guidelines, including those published in Canada, widespread testing for H pylori infection is not recommended. This practice is not encouraged because of insufficient evidence of cost-benefit in gastric cancer prevention, the potential for increases in antibiotic resistance and the controversial hypothesis of potential negative effects of eradication in certain clinical entities. For example, there is insufficient evidence to recommend against eradicating H pylori discovered in a patient with symptoms of gastroesophageal reflux disease. The management guidelines designed specifically in Canada should, therefore, continue to be applied, with H pylori diagnosed and treated in appropriately selected patients.http://dx.doi.org/10.1155/2002/202961
spellingShingle Richard H Hunt
Carlo Fallone
Sander Veldhuyzen van Zanten
Phil Sherman
Fiona Smaill
Alan BR Thomson
the Canadian Helicobacter Study Group
Risks and Benefits of Helicobacter pylori Eradication: Current Status
Canadian Journal of Gastroenterology
title Risks and Benefits of Helicobacter pylori Eradication: Current Status
title_full Risks and Benefits of Helicobacter pylori Eradication: Current Status
title_fullStr Risks and Benefits of Helicobacter pylori Eradication: Current Status
title_full_unstemmed Risks and Benefits of Helicobacter pylori Eradication: Current Status
title_short Risks and Benefits of Helicobacter pylori Eradication: Current Status
title_sort risks and benefits of helicobacter pylori eradication current status
url http://dx.doi.org/10.1155/2002/202961
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