Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.

Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone-T-zone boun...

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Bibliographic Details
Main Authors: Takaharu Okada, Mark J Miller, Ian Parker, Matthew F Krummel, Margaret Neighbors, Suzanne B Hartley, Anne O'Garra, Michael D Cahalan, Jason G Cyster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-06-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0030150&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0030150&type=printable

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