Androgen receptor signaling in the lungs mitigates inflammation and improves the outcome of influenza in mice.

Androgen receptor signaling in the lungs mitigates inflammation and improves the outcome of influenza in mice.

Circulating androgens can modulate immune cell activity, but the impact of androgens on viral pathogenesis remains unclear. Previous data demonstrate that testosterone reduces the severity of influenza A virus (IAV) infection in male mice by mitigating pulmonary inflammation rather than by affecting...

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Bibliographic Details
Main Authors: Landon G Vom Steeg, Santosh Dhakal, Yishak A Woldetsadik, Han-Sol Park, Kathleen R Mulka, Emma C Reilly, David J Topham, Sabra L Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008506&type=printable
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