Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health
Akkermansia muciniphila (A. muciniphila) is a functional gut commensal bacterium. The imbalance in the distribution and abundance of A. muciniphila in the gastrointestinal tract is closely related to the occurrence of various diseases, including glucolipid metabolic disorders and enteritis. This rev...
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The editorial department of Science and Technology of Food Industry
2025-04-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024060336 |
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| author | Yijia XI Haiyu PAN Zhenglin WU Guihu XU Xiaoyin LI Yanhua GAO |
| author_facet | Yijia XI Haiyu PAN Zhenglin WU Guihu XU Xiaoyin LI Yanhua GAO |
| author_sort | Yijia XI |
| collection | DOAJ |
| description | Akkermansia muciniphila (A. muciniphila) is a functional gut commensal bacterium. The imbalance in the distribution and abundance of A. muciniphila in the gastrointestinal tract is closely related to the occurrence of various diseases, including glucolipid metabolic disorders and enteritis. This review aims to provide a concise overview of the probiotic function of A. muciniphila in regulating glucose and lipid metabolism, alleviating intestinal inflammation, and enhancing intestinal barrier function, as well as its molecular mechanism of action. Meanwhile, to tackle the challenges of industrial applying A. muciniphila, such as defining a safe and effective supplemental dosage and creating a cost-efficient, high-density production process, new research directions are proposed to guide the development of A. muciniphila as a novel probiotic additive. |
| format | Article |
| id | doaj-art-8972a92e02a140d3be7e19b407d1ea74 |
| institution | OA Journals |
| issn | 1002-0306 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj-art-8972a92e02a140d3be7e19b407d1ea742025-08-20T02:16:33ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062025-04-0146843144010.13386/j.issn1002-0306.20240603362024060336-8Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal HealthYijia XI0Haiyu PAN1Zhenglin WU2Guihu XU3Xiaoyin LI4Yanhua GAO5Key Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, ChinaAkkermansia muciniphila (A. muciniphila) is a functional gut commensal bacterium. The imbalance in the distribution and abundance of A. muciniphila in the gastrointestinal tract is closely related to the occurrence of various diseases, including glucolipid metabolic disorders and enteritis. This review aims to provide a concise overview of the probiotic function of A. muciniphila in regulating glucose and lipid metabolism, alleviating intestinal inflammation, and enhancing intestinal barrier function, as well as its molecular mechanism of action. Meanwhile, to tackle the challenges of industrial applying A. muciniphila, such as defining a safe and effective supplemental dosage and creating a cost-efficient, high-density production process, new research directions are proposed to guide the development of A. muciniphila as a novel probiotic additive.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024060336akkermansia muciniphilaprobioticsglucolipid metabolismintestinal healthmolecular mechanism of action |
| spellingShingle | Yijia XI Haiyu PAN Zhenglin WU Guihu XU Xiaoyin LI Yanhua GAO Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health Shipin gongye ke-ji akkermansia muciniphila probiotics glucolipid metabolism intestinal health molecular mechanism of action |
| title | Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health |
| title_full | Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health |
| title_fullStr | Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health |
| title_full_unstemmed | Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health |
| title_short | Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health |
| title_sort | research progress on regulatory effects and mechanism of akkermansia muciniphila on glycolipid metabolism and intestinal health |
| topic | akkermansia muciniphila probiotics glucolipid metabolism intestinal health molecular mechanism of action |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024060336 |
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