Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial
Glycosaminoglycans or sulodexide has shown benefits in early experimental diabetic nephropathy (DN) models, but its efficacy in patients with early stage of DN is unknown. Methods. Twenty patients were randomly assigned to the placebo group and another 20 patients were randomly assigned to receive s...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/172038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550989640499200 |
|---|---|
| author | Bancha Satirapoj Wisit Kaewput Ouppatham Supasyndh Prajej Ruangkanchanasetr |
| author_facet | Bancha Satirapoj Wisit Kaewput Ouppatham Supasyndh Prajej Ruangkanchanasetr |
| author_sort | Bancha Satirapoj |
| collection | DOAJ |
| description | Glycosaminoglycans or sulodexide has shown benefits in early experimental diabetic nephropathy (DN) models, but its efficacy in patients with early stage of DN is unknown. Methods. Twenty patients were randomly assigned to the placebo group and another 20 patients were randomly assigned to receive sulodexide 100 mg/day for 14 weeks. Primary outcome was a change of urinary TGF-beta1, albuminuria, and glomerular filtration rate (GFR). All patients had stable metabolic profiles for at least 90 days before randomization. Results. Urinary TGF-beta1 increased significantly in the placebo group but did not change significantly in the sulodexide group. Additionally, the mean change of urine TGF-beta1 in the placebo group was significantly higher than that in the sulodexide group (8.44±9.21 versus 2.17±6.96 pg/mg Cr, P=0.02). Mean changes of urinary albumin were 15.05±30.09 μg/mg Cr (P=0.038) in the placebo group and 13.89±32.25 μg/mg Cr (P=0.069) in the sulodexide group. No consistent patterns of side effects were observed. Conclusion. In this 14-week trial, benefits of sulodexide in preventing the increase of urinary TGF-beta1 were observed in patients with normoalbuminuric type 2 diabetes. The study suggests that sulodexide treatment may provide additional renoprotection in early stage DN. This trial is registered with TCTR20140806001. |
| format | Article |
| id | doaj-art-897276992a164cc3b1299695b61db757 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-897276992a164cc3b1299695b61db7572025-02-03T06:05:19ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/172038172038Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled TrialBancha Satirapoj0Wisit Kaewput1Ouppatham Supasyndh2Prajej Ruangkanchanasetr3Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, ThailandDivision of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, ThailandDivision of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, ThailandDivision of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, ThailandGlycosaminoglycans or sulodexide has shown benefits in early experimental diabetic nephropathy (DN) models, but its efficacy in patients with early stage of DN is unknown. Methods. Twenty patients were randomly assigned to the placebo group and another 20 patients were randomly assigned to receive sulodexide 100 mg/day for 14 weeks. Primary outcome was a change of urinary TGF-beta1, albuminuria, and glomerular filtration rate (GFR). All patients had stable metabolic profiles for at least 90 days before randomization. Results. Urinary TGF-beta1 increased significantly in the placebo group but did not change significantly in the sulodexide group. Additionally, the mean change of urine TGF-beta1 in the placebo group was significantly higher than that in the sulodexide group (8.44±9.21 versus 2.17±6.96 pg/mg Cr, P=0.02). Mean changes of urinary albumin were 15.05±30.09 μg/mg Cr (P=0.038) in the placebo group and 13.89±32.25 μg/mg Cr (P=0.069) in the sulodexide group. No consistent patterns of side effects were observed. Conclusion. In this 14-week trial, benefits of sulodexide in preventing the increase of urinary TGF-beta1 were observed in patients with normoalbuminuric type 2 diabetes. The study suggests that sulodexide treatment may provide additional renoprotection in early stage DN. This trial is registered with TCTR20140806001.http://dx.doi.org/10.1155/2015/172038 |
| spellingShingle | Bancha Satirapoj Wisit Kaewput Ouppatham Supasyndh Prajej Ruangkanchanasetr Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial Journal of Diabetes Research |
| title | Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial |
| title_full | Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial |
| title_fullStr | Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial |
| title_full_unstemmed | Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial |
| title_short | Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial |
| title_sort | effect of sulodexide on urinary biomarkers of kidney injury in normoalbuminuric type 2 diabetes a randomized controlled trial |
| url | http://dx.doi.org/10.1155/2015/172038 |
| work_keys_str_mv | AT banchasatirapoj effectofsulodexideonurinarybiomarkersofkidneyinjuryinnormoalbuminurictype2diabetesarandomizedcontrolledtrial AT wisitkaewput effectofsulodexideonurinarybiomarkersofkidneyinjuryinnormoalbuminurictype2diabetesarandomizedcontrolledtrial AT ouppathamsupasyndh effectofsulodexideonurinarybiomarkersofkidneyinjuryinnormoalbuminurictype2diabetesarandomizedcontrolledtrial AT prajejruangkanchanasetr effectofsulodexideonurinarybiomarkersofkidneyinjuryinnormoalbuminurictype2diabetesarandomizedcontrolledtrial |