Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors
Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozy...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2017-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/951 |
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| author | Özden Turan Deniz Anuk-İnce Lale Olcay Taner Sezer Kaan Gülleroğlu Zerrin Yılmaz-Çelik Ayşe Ecevit |
| author_facet | Özden Turan Deniz Anuk-İnce Lale Olcay Taner Sezer Kaan Gülleroğlu Zerrin Yılmaz-Çelik Ayşe Ecevit |
| author_sort | Özden Turan |
| collection | DOAJ |
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Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozygous polymorphism and the other case had both MTHFR A1298C homozygous polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/ 5G polymorphism and elevated lipoprotein a. Early diagnosis and prompt initiation of therapy of neonatal CSVT may prevent neonatal mortality and poor long-term neurodevelopmental outcomes.
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| format | Article |
| id | doaj-art-8970b5772aa4458497e61db2f7eaa048 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8970b5772aa4458497e61db2f7eaa0482025-08-20T03:00:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212017-02-0159110.24953/turkjped.2017.01.012Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factorsÖzden Turan0Deniz Anuk-İnce1Lale Olcay2Taner Sezer3Kaan Gülleroğlu4Zerrin Yılmaz-Çelik5Ayşe Ecevit6Divisions of Neonatology, Baskent University Faculty of Medicine, Ankara, Turkey.Divisions of Neonatology, Baskent University Faculty of Medicine, Ankara, Turkey.Divisions of Pediatric Hematology, Baskent University Faculty of Medicine, Ankara, Turkey.Divisions of Pediatric Neurology, Baskent University Faculty of Medicine, Ankara, Turkey.Divisions of Pediatric Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.Department of Medical Genetics, Baskent University Faculty of Medicine, Ankara, Turkey.Divisions of Neonatology, Baskent University Faculty of Medicine, Ankara, Turkey. Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozygous polymorphism and the other case had both MTHFR A1298C homozygous polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/ 5G polymorphism and elevated lipoprotein a. Early diagnosis and prompt initiation of therapy of neonatal CSVT may prevent neonatal mortality and poor long-term neurodevelopmental outcomes. https://turkjpediatr.org/article/view/951anticoagulationcerebral sinovenous thrombosisnewborn |
| spellingShingle | Özden Turan Deniz Anuk-İnce Lale Olcay Taner Sezer Kaan Gülleroğlu Zerrin Yılmaz-Çelik Ayşe Ecevit Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors The Turkish Journal of Pediatrics anticoagulation cerebral sinovenous thrombosis newborn |
| title | Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors |
| title_full | Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors |
| title_fullStr | Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors |
| title_full_unstemmed | Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors |
| title_short | Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors |
| title_sort | neonatal cerebral sinovenous thrombosis two cases two different gene polymorphisms and risk factors |
| topic | anticoagulation cerebral sinovenous thrombosis newborn |
| url | https://turkjpediatr.org/article/view/951 |
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