Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Abstract G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global...

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Main Authors: Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar
Format: Article
Language:English
Published: Springer Nature 2017-03-01
Series:Molecular Systems Biology
Subjects:
G‐protein‐coupled receptors
high‐throughput screening
integrative computational biology
interactome
protein–protein interactions
split‐ubiquitin membrane yeast two‐hybrid assay
Online Access:https://doi.org/10.15252/msb.20167430
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