HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study
Conclusions: High HbA1c levels increase the risk of lower limb ulcers in diabetic patients. MR analyses validated the positive but not significant association between genetically proxied HbA1c levels and lower limb ulcer risk. The results recommended an HbA1c goal of < 53 mmol/mol to decrease the...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/4744194 |
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| _version_ | 1849765021297410048 |
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| author | Guojun Guo Yunlong Guan Yuhuan Chen Yuge Ye Zeyu Gan Xi Cao Zhenbing Chen Xingjie Hao |
| author_facet | Guojun Guo Yunlong Guan Yuhuan Chen Yuge Ye Zeyu Gan Xi Cao Zhenbing Chen Xingjie Hao |
| author_sort | Guojun Guo |
| collection | DOAJ |
| description | Conclusions: High HbA1c levels increase the risk of lower limb ulcers in diabetic patients. MR analyses validated the positive but not significant association between genetically proxied HbA1c levels and lower limb ulcer risk. The results recommended an HbA1c goal of < 53 mmol/mol to decrease the incidence of diabetic ulcers. |
| format | Article |
| id | doaj-art-8960eccde2da4861aa02e4402d6e8d7d |
| institution | DOAJ |
| issn | 2314-6753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8960eccde2da4861aa02e4402d6e8d7d2025-08-20T03:04:58ZengWileyJournal of Diabetes Research2314-67532025-01-01202510.1155/jdr/4744194HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics StudyGuojun Guo0Yunlong Guan1Yuhuan Chen2Yuge Ye3Zeyu Gan4Xi Cao5Zhenbing Chen6Xingjie Hao7Department of Hand SurgeryDepartment of Epidemiology and BiostatisticsDepartment of Epidemiology and BiostatisticsDepartment of Epidemiology and BiostatisticsDepartment of Epidemiology and BiostatisticsDepartment of Epidemiology and BiostatisticsDepartment of Hand SurgeryDepartment of Epidemiology and BiostatisticsConclusions: High HbA1c levels increase the risk of lower limb ulcers in diabetic patients. MR analyses validated the positive but not significant association between genetically proxied HbA1c levels and lower limb ulcer risk. The results recommended an HbA1c goal of < 53 mmol/mol to decrease the incidence of diabetic ulcers.http://dx.doi.org/10.1155/jdr/4744194 |
| spellingShingle | Guojun Guo Yunlong Guan Yuhuan Chen Yuge Ye Zeyu Gan Xi Cao Zhenbing Chen Xingjie Hao HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study Journal of Diabetes Research |
| title | HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study |
| title_full | HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study |
| title_fullStr | HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study |
| title_full_unstemmed | HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study |
| title_short | HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study |
| title_sort | hba1c and the risk of lower limb ulcers among diabetic patients an observational and genetics study |
| url | http://dx.doi.org/10.1155/jdr/4744194 |
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