Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population.
In recent years, the incidence of tuberculosis (TB) has declined worldwide, although this disease still occurs at relatively high rates in Amerindian populations. This suggests that the genetic ancestry of Amerindians may be an important factor in the development of infections, and may account for a...
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236033&type=printable |
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| author | Diana Feio da Veiga Borges Leal Mayara Natália Santana da Silva Débora Cristina Ricardo de Oliveira Fernandes Juliana Carla Gomes Rodrigues Maria Clara da Costa Barros Pablo Diego do Carmo Pinto Lucas Favacho Pastana Cleonardo Augusto da Silva Marianne Rodrigues Fernandes Paulo Pimentel de Assumpção Sidney Emanuel Batista Dos Santos Ney Pereira Carneiro Dos Santos |
| author_facet | Diana Feio da Veiga Borges Leal Mayara Natália Santana da Silva Débora Cristina Ricardo de Oliveira Fernandes Juliana Carla Gomes Rodrigues Maria Clara da Costa Barros Pablo Diego do Carmo Pinto Lucas Favacho Pastana Cleonardo Augusto da Silva Marianne Rodrigues Fernandes Paulo Pimentel de Assumpção Sidney Emanuel Batista Dos Santos Ney Pereira Carneiro Dos Santos |
| author_sort | Diana Feio da Veiga Borges Leal |
| collection | DOAJ |
| description | In recent years, the incidence of tuberculosis (TB) has declined worldwide, although this disease still occurs at relatively high rates in Amerindian populations. This suggests that the genetic ancestry of Amerindians may be an important factor in the development of infections, and may account for at least some of the variation in infection rates in the different populations. The present study investigated the potential influence of Amerindian genetic ancestry on susceptibility to tuberculosis in an Amazon population. The study included 280 patients diagnosed with tuberculosis and 138 asymptomatic hospital employees with no history of TB, but who were in contact with bacterially active TB patients. Ancestry analysis was run on a set of 61 Ancestry-Informative Markers to estimate European, African, and Amerindian genetic ancestry using STRUCTURE v2.2. The TB group had significantly higher Amerindian ancestry in comparison with the control group, and significantly lower European ancestry. Amerindian ancestry in the 20-60% range was found to be the principal risk factor for increased susceptibility to TB. The results of the study indicate that Amerindian ancestry is an important risk factor for susceptibility to TB in the admixed population of the Brazilian Amazon region. |
| format | Article |
| id | doaj-art-895c4aaf01b246a48804bcce3cfd6dc2 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-895c4aaf01b246a48804bcce3cfd6dc22025-08-20T02:10:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023603310.1371/journal.pone.0236033Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population.Diana Feio da Veiga Borges LealMayara Natália Santana da SilvaDébora Cristina Ricardo de Oliveira FernandesJuliana Carla Gomes RodriguesMaria Clara da Costa BarrosPablo Diego do Carmo PintoLucas Favacho PastanaCleonardo Augusto da SilvaMarianne Rodrigues FernandesPaulo Pimentel de AssumpçãoSidney Emanuel Batista Dos SantosNey Pereira Carneiro Dos SantosIn recent years, the incidence of tuberculosis (TB) has declined worldwide, although this disease still occurs at relatively high rates in Amerindian populations. This suggests that the genetic ancestry of Amerindians may be an important factor in the development of infections, and may account for at least some of the variation in infection rates in the different populations. The present study investigated the potential influence of Amerindian genetic ancestry on susceptibility to tuberculosis in an Amazon population. The study included 280 patients diagnosed with tuberculosis and 138 asymptomatic hospital employees with no history of TB, but who were in contact with bacterially active TB patients. Ancestry analysis was run on a set of 61 Ancestry-Informative Markers to estimate European, African, and Amerindian genetic ancestry using STRUCTURE v2.2. The TB group had significantly higher Amerindian ancestry in comparison with the control group, and significantly lower European ancestry. Amerindian ancestry in the 20-60% range was found to be the principal risk factor for increased susceptibility to TB. The results of the study indicate that Amerindian ancestry is an important risk factor for susceptibility to TB in the admixed population of the Brazilian Amazon region.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236033&type=printable |
| spellingShingle | Diana Feio da Veiga Borges Leal Mayara Natália Santana da Silva Débora Cristina Ricardo de Oliveira Fernandes Juliana Carla Gomes Rodrigues Maria Clara da Costa Barros Pablo Diego do Carmo Pinto Lucas Favacho Pastana Cleonardo Augusto da Silva Marianne Rodrigues Fernandes Paulo Pimentel de Assumpção Sidney Emanuel Batista Dos Santos Ney Pereira Carneiro Dos Santos Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population. PLoS ONE |
| title | Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population. |
| title_full | Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population. |
| title_fullStr | Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population. |
| title_full_unstemmed | Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population. |
| title_short | Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population. |
| title_sort | amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236033&type=printable |
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