Self‐Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug‐Enzyme Assembly for Antitumor Therapy

Self‐Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug‐Enzyme Assembly for Antitumor Therapy

Abstract Endogenous stimuli‐responsive prodrugs, due to their disease lesion specificity and reduced systemic toxicity, have been widely explored for antitumor therapy. However, reactive oxygen species (ROS) as classical endogenous stimuli in the tumor microenvironment (TME) are not enough to achiev...

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Bibliographic Details
Main Authors: Shanshan Jiang, Bhaskar Gurram, Junfei Zhu, Shan Lei, Yifan Zhang, Ting He, Oya Tagit, Hui Fang, Peng Huang, Jing Lin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
antitumor therapy
glucose oxidase
heterodimeric prodrug
reactive oxygen species
self‐boosted programmable release
Online Access:https://doi.org/10.1002/advs.202409960
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