Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study
Introduction: Cervical cancer is the fourth most common cancer affecting women worldwide, following breast, colorectal and lung cancer. India contributes 28% of the cervical cancer mortality burden, with 87,090 deaths due to cervical cancer, making it the second most populous country in the worl...
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JCDR Research and Publications Private Limited
2025-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/20592/73897_CE(Ra1)_F(Sh)_QC(AN_SS)_PF1(AG_SS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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| author | Shrabani Mitra Deepankar Shriwas Madhumita Mondal Gouri Sankar Kamilya Asim Kumar Manna |
| author_facet | Shrabani Mitra Deepankar Shriwas Madhumita Mondal Gouri Sankar Kamilya Asim Kumar Manna |
| author_sort | Shrabani Mitra |
| collection | DOAJ |
| description | Introduction: Cervical cancer is the fourth most common
cancer affecting women worldwide, following breast, colorectal
and lung cancer. India contributes 28% of the cervical cancer
mortality burden, with 87,090 deaths due to cervical cancer,
making it the second most populous country in the world.
Oestrogen Receptors (ER) are located not only in the tissues
of the female reproductive tract and breast but also in diverse
tissues such as bone, brain, liver, colon, skin and salivary
glands. Ki-67 is a nuclear protein expressed during all active
phases of the cell cycle and is absent in the G0 phase, making
it a potent biomarker of cellular proliferation.
Aim: To study the clinicopathological spectrum of cervical
epithelial lesions and their association with cell proliferation (Ki67) and ER and Progesterone Receptor (PR) status.
Materials and Methods: This was a single-institution-based
cross-sectional study in which a total of 202 cases of cervical
epithelial lesions diagnosed from May 2022 to May 2024 at the
Institute of Post Graduate Medical Education and Research
and SSKM Hospital, Kolkata, West Bengal, India were studied.
Clinical and demographic data were associated with histological
findings. Immunohistochemical staining with Ki-67, ER and PR
antibodies was performed and the Ki-67 labelling index and
ER and PR status were assessed respectively. Based on the
assessment, a master chart was prepared for patients belonging
to different age groups with certain medical complaints, and data
were organised into tables. Statistical analysis was conducted
using Microsoft Excel and Statistical Package for the Social
Sciences (SPSS) version 23.0 software.
Results: In this study, 202 patients were evaluated. The patient
age ranged from 18 to 68 years, with a mean age of 40.78±10.13
years. Cervical epithelial lesions were most prevalent in the age
group of 31 to 50 years (66.8%). Among the 202 cases, 108
(53.5%) were non neoplastic, 10 cases (5.0%) were benign
neoplastic, and 84 cases (41.6%) were malignant neoplastic
lesions. The difference in proliferative rates, as indicated by the
Ki-67 labelling index, between benign neoplasms and malignant
neoplasms was statistically significant (p-value <0.001). There
was no significant association between the levels of ER and the
nature of the lesions in the patients (non neoplastic and neoplastic)
(p-value=0.08). Additionally, there was no significant association
between the levels of PR and the nature of the lesions in the
patients (p-value=0.25).
Conclusion: Malignant neoplasms exhibit a significantly
higher proliferative rate than benign neoplasms and non
neoplastic lesions. No significant association between ER
and PR status and the nature of the lesions was found in
the study, although the mean ER score and mean PR score
of adenocarcinomas were significantly higher than those of
Squamous Cell Carcinoma (SCC) and Cervical Intraepithelial
Neoplasia (CIN). |
| format | Article |
| id | doaj-art-895452a8cba94b358e92fbd17c4eecb6 |
| institution | OA Journals |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-895452a8cba94b358e92fbd17c4eecb62025-08-20T02:26:06ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-02-01192010610.7860/JCDR/2025/73897.20592Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional StudyShrabani Mitra0Deepankar Shriwas1Madhumita Mondal2Gouri Sankar Kamilya3Asim Kumar Manna4Trainee, Department of Pathology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India.Trainee, Department of Pathology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India.Assistant Professor, Department of Pathology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India.Professor, Department of Obstetrics and Gynaecology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India.Professor, Department of Pathology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India.Introduction: Cervical cancer is the fourth most common cancer affecting women worldwide, following breast, colorectal and lung cancer. India contributes 28% of the cervical cancer mortality burden, with 87,090 deaths due to cervical cancer, making it the second most populous country in the world. Oestrogen Receptors (ER) are located not only in the tissues of the female reproductive tract and breast but also in diverse tissues such as bone, brain, liver, colon, skin and salivary glands. Ki-67 is a nuclear protein expressed during all active phases of the cell cycle and is absent in the G0 phase, making it a potent biomarker of cellular proliferation. Aim: To study the clinicopathological spectrum of cervical epithelial lesions and their association with cell proliferation (Ki67) and ER and Progesterone Receptor (PR) status. Materials and Methods: This was a single-institution-based cross-sectional study in which a total of 202 cases of cervical epithelial lesions diagnosed from May 2022 to May 2024 at the Institute of Post Graduate Medical Education and Research and SSKM Hospital, Kolkata, West Bengal, India were studied. Clinical and demographic data were associated with histological findings. Immunohistochemical staining with Ki-67, ER and PR antibodies was performed and the Ki-67 labelling index and ER and PR status were assessed respectively. Based on the assessment, a master chart was prepared for patients belonging to different age groups with certain medical complaints, and data were organised into tables. Statistical analysis was conducted using Microsoft Excel and Statistical Package for the Social Sciences (SPSS) version 23.0 software. Results: In this study, 202 patients were evaluated. The patient age ranged from 18 to 68 years, with a mean age of 40.78±10.13 years. Cervical epithelial lesions were most prevalent in the age group of 31 to 50 years (66.8%). Among the 202 cases, 108 (53.5%) were non neoplastic, 10 cases (5.0%) were benign neoplastic, and 84 cases (41.6%) were malignant neoplastic lesions. The difference in proliferative rates, as indicated by the Ki-67 labelling index, between benign neoplasms and malignant neoplasms was statistically significant (p-value <0.001). There was no significant association between the levels of ER and the nature of the lesions in the patients (non neoplastic and neoplastic) (p-value=0.08). Additionally, there was no significant association between the levels of PR and the nature of the lesions in the patients (p-value=0.25). Conclusion: Malignant neoplasms exhibit a significantly higher proliferative rate than benign neoplasms and non neoplastic lesions. No significant association between ER and PR status and the nature of the lesions was found in the study, although the mean ER score and mean PR score of adenocarcinomas were significantly higher than those of Squamous Cell Carcinoma (SCC) and Cervical Intraepithelial Neoplasia (CIN).https://jcdr.net/articles/PDF/20592/73897_CE(Ra1)_F(Sh)_QC(AN_SS)_PF1(AG_SS)_PFA(IS)_PB(AG_IS)_PN(IS).pdfcell proliferation markercervical neoplasmhormonal statusimmunohistochemistry |
| spellingShingle | Shrabani Mitra Deepankar Shriwas Madhumita Mondal Gouri Sankar Kamilya Asim Kumar Manna Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study Journal of Clinical and Diagnostic Research cell proliferation marker cervical neoplasm hormonal status immunohistochemistry |
| title | Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study |
| title_full | Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study |
| title_fullStr | Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study |
| title_full_unstemmed | Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study |
| title_short | Role of Proliferative Marker (Ki-67) and ER, PR in Cervical Epithelial Lesions with Clinicopathological Association: A Cross-sectional Study |
| title_sort | role of proliferative marker ki 67 and er pr in cervical epithelial lesions with clinicopathological association a cross sectional study |
| topic | cell proliferation marker cervical neoplasm hormonal status immunohistochemistry |
| url | https://jcdr.net/articles/PDF/20592/73897_CE(Ra1)_F(Sh)_QC(AN_SS)_PF1(AG_SS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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