Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/145654 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564763453816832 |
|---|---|
| author | Zhou Zhou Weiliang Sun Ying Liang Yanxiang Gao Wei Kong Youfei Guan Juan Feng Xian Wang |
| author_facet | Zhou Zhou Weiliang Sun Ying Liang Yanxiang Gao Wei Kong Youfei Guan Juan Feng Xian Wang |
| author_sort | Zhou Zhou |
| collection | DOAJ |
| description | Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an important role in autoimmune diseases and inflammatory diseases. Previous papers have revealed that a lipid-lowering synthetic ligand of peroxisome proliferator-activated receptor α (PPARα), fenofibrate, alleviates both atherosclerosis and a few nonlipid-associated autoimmune diseases such as autoimmune colitis and multiple sclerosis. However, the link between fenofibrate and Th17 cells is lacking. In the present study, we hypothesized that fenofibrate inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-β (TGF-β) and IL-6-induced differentiation of Th17 cells in vitro. However, other PPARα ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPARα independent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases. |
| format | Article |
| id | doaj-art-89535c3a729c44c0861cf1ba3d518636 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-89535c3a729c44c0861cf1ba3d5186362025-02-03T01:10:17ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/145654145654Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In VitroZhou Zhou0Weiliang Sun1Ying Liang2Yanxiang Gao3Wei Kong4Youfei Guan5Juan Feng6Xian Wang7Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, ChinaUncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an important role in autoimmune diseases and inflammatory diseases. Previous papers have revealed that a lipid-lowering synthetic ligand of peroxisome proliferator-activated receptor α (PPARα), fenofibrate, alleviates both atherosclerosis and a few nonlipid-associated autoimmune diseases such as autoimmune colitis and multiple sclerosis. However, the link between fenofibrate and Th17 cells is lacking. In the present study, we hypothesized that fenofibrate inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-β (TGF-β) and IL-6-induced differentiation of Th17 cells in vitro. However, other PPARα ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPARα independent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.http://dx.doi.org/10.1155/2012/145654 |
| spellingShingle | Zhou Zhou Weiliang Sun Ying Liang Yanxiang Gao Wei Kong Youfei Guan Juan Feng Xian Wang Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro PPAR Research |
| title | Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro |
| title_full | Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro |
| title_fullStr | Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro |
| title_full_unstemmed | Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro |
| title_short | Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro |
| title_sort | fenofibrate inhibited the differentiation of t helper 17 cells in vitro |
| url | http://dx.doi.org/10.1155/2012/145654 |
| work_keys_str_mv | AT zhouzhou fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT weiliangsun fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT yingliang fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT yanxianggao fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT weikong fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT youfeiguan fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT juanfeng fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro AT xianwang fenofibrateinhibitedthedifferentiationofthelper17cellsinvitro |