Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study
Introduction and Objectives: Nonalcoholic fatty liver disease (NAFLD) is a common clinical condition and an important public health problem. Some epidemiological studies have suggested that soft drinks (SD) intake is associated with NAFLD. However, the evidence is inconsistent. Our objective was to...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268124003491 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693575084769280 |
|---|---|
| author | Edgar Denova-Gutiérrez Berenice Rivera-Paredez Amado D. Quezada-Sánchez Brianda I. Armenta-Guirado Paloma Muñoz-Aguirre Yvonne N. Flores Rafael Velázquez-Cruz Jorge Salmerón |
| author_facet | Edgar Denova-Gutiérrez Berenice Rivera-Paredez Amado D. Quezada-Sánchez Brianda I. Armenta-Guirado Paloma Muñoz-Aguirre Yvonne N. Flores Rafael Velázquez-Cruz Jorge Salmerón |
| author_sort | Edgar Denova-Gutiérrez |
| collection | DOAJ |
| description | Introduction and Objectives: Nonalcoholic fatty liver disease (NAFLD) is a common clinical condition and an important public health problem. Some epidemiological studies have suggested that soft drinks (SD) intake is associated with NAFLD. However, the evidence is inconsistent. Our objective was to assess the association between SD consumption and the risk of NAFLD in a Mexican adult population. Materials and Methods: A total of 1,759 participants from the Health Workers Cohort Study (HWCS) were included in the analyses. SD intake was measured using a validated food frequency questionnaire. We classified SD consumption as follows: a) less than 1 serving per week, b) 1 to less than 3.5 servings per week, and c) 3.5 or more servings per week. Hepatic steatosis index (HSI) was calculated based on sex, BMI, and blood transaminase levels, and was categorized as NAFLD ≥ 36. To assess the relation between SD and NAFLD, we followed two approaches: fixed effects logistic regression and generalized estimating equations. Results: After adjusting for demographic characteristics, lifestyle factors, and dietary intake, the odds ratio (OR) and 95 % confidence interval (95 % CI) for NAFLD were 1.26 (95 % CI: 1.08, 1.48) for 1 to less than 3.5 servings per week and 1.42 (95 % CI: 1.19, 1.69) for ≥3.5 servings/week category in both sexes. When stratifying the analysis by sex, we observed that the association tended to be greater in men than in women. Conclusions: The results from our prospective study indicate that SD consumption is associated with an increased risk of NAFLD. |
| format | Article |
| id | doaj-art-894cfa2f26614fe4a7d5132e8bc4b847 |
| institution | DOAJ |
| issn | 1665-2681 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj-art-894cfa2f26614fe4a7d5132e8bc4b8472025-08-20T03:20:22ZengElsevierAnnals of Hepatology1665-26812025-01-0130110156610.1016/j.aohep.2024.101566Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort studyEdgar Denova-Gutiérrez0Berenice Rivera-Paredez1Amado D. Quezada-Sánchez2Brianda I. Armenta-Guirado3Paloma Muñoz-Aguirre4Yvonne N. Flores5Rafael Velázquez-Cruz6Jorge Salmerón7Center for Research in Nutrition and Health, Mexican National Institute of Public Health, Cuernavaca, Mexico; Corresponding authors.Center for Research in Policies, Population and Health, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; Corresponding authors.Center for Evaluation and Surveys Research, National Institute of Public Health, Cuernavaca, MexicoDepartment of Health Sciences, University of Sonora, MéxicoConsejo Nacional de Humanidades, Ciencias y Tecnologías and Center for Population Health Research, National Institute of Public Health, Cuernavaca, MexicoUnidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, Mexico; UCLA Department of Health Policy and Management, Center for Cancer Prevention and Control Research, and UCLA Kaiser Permanente Center for Health Equity, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, USAGenomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine, Mexico City, MexicoCenter for Research in Policies, Population and Health, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, MexicoIntroduction and Objectives: Nonalcoholic fatty liver disease (NAFLD) is a common clinical condition and an important public health problem. Some epidemiological studies have suggested that soft drinks (SD) intake is associated with NAFLD. However, the evidence is inconsistent. Our objective was to assess the association between SD consumption and the risk of NAFLD in a Mexican adult population. Materials and Methods: A total of 1,759 participants from the Health Workers Cohort Study (HWCS) were included in the analyses. SD intake was measured using a validated food frequency questionnaire. We classified SD consumption as follows: a) less than 1 serving per week, b) 1 to less than 3.5 servings per week, and c) 3.5 or more servings per week. Hepatic steatosis index (HSI) was calculated based on sex, BMI, and blood transaminase levels, and was categorized as NAFLD ≥ 36. To assess the relation between SD and NAFLD, we followed two approaches: fixed effects logistic regression and generalized estimating equations. Results: After adjusting for demographic characteristics, lifestyle factors, and dietary intake, the odds ratio (OR) and 95 % confidence interval (95 % CI) for NAFLD were 1.26 (95 % CI: 1.08, 1.48) for 1 to less than 3.5 servings per week and 1.42 (95 % CI: 1.19, 1.69) for ≥3.5 servings/week category in both sexes. When stratifying the analysis by sex, we observed that the association tended to be greater in men than in women. Conclusions: The results from our prospective study indicate that SD consumption is associated with an increased risk of NAFLD.http://www.sciencedirect.com/science/article/pii/S1665268124003491Soft drinkConsumptionNonalcoholic fatty liver diseaseCohort study |
| spellingShingle | Edgar Denova-Gutiérrez Berenice Rivera-Paredez Amado D. Quezada-Sánchez Brianda I. Armenta-Guirado Paloma Muñoz-Aguirre Yvonne N. Flores Rafael Velázquez-Cruz Jorge Salmerón Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study Annals of Hepatology Soft drink Consumption Nonalcoholic fatty liver disease Cohort study |
| title | Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study |
| title_full | Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study |
| title_fullStr | Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study |
| title_full_unstemmed | Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study |
| title_short | Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study |
| title_sort | soft drink consumption and increased risk of nonalcoholic fatty liver disease results from the health workers cohort study |
| topic | Soft drink Consumption Nonalcoholic fatty liver disease Cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S1665268124003491 |
| work_keys_str_mv | AT edgardenovagutierrez softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT bereniceriveraparedez softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT amadodquezadasanchez softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT briandaiarmentaguirado softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT palomamunozaguirre softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT yvonnenflores softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT rafaelvelazquezcruz softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy AT jorgesalmeron softdrinkconsumptionandincreasedriskofnonalcoholicfattyliverdiseaseresultsfromthehealthworkerscohortstudy |