Collagen–Platelet-Rich Plasma Mixed Hydrogels as a pBMP2 Delivery System for Bone Defect Regeneration

Collagen–Platelet-Rich Plasma Mixed Hydrogels as a pBMP2 Delivery System for Bone Defect Regeneration

<b>Background/Objectives:</b> The replenishment of bone deficiency remains a challenging task in clinical practice. The use of gene-activated matrices (GAMs) impregnated with genetic constructs may be an innovative approach to solving this problem. The aim of this work is to develop coll...

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Main Authors: Anastasiia Yurevna Meglei, Irina Alekseevna Nedorubova, Viktoriia Pavlovna Basina, Viktoria Olegovna Chernomyrdina, Andrey Anatolevich Nedorubov, Valeriya Sergeevna Kuznetsova, Andrey Vyacheslavovich Vasilyev, Sergey Ivanovich Kutsev, Dmitry Vadimovich Goldshtein, Tatiana Borisovna Bukharova
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomedicines
Subjects:
gene-activated matrices
BMP2
non-viral delivery
collagen I
platelet-rich plasma
critical size bone defect
Online Access:https://www.mdpi.com/2227-9059/12/11/2461
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