Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island
Objectives. We evaluated the efficacy of magnesium sulfate as a second-line tocolysis for 48 hours. Materials and Methods. A multi-institutional, simple 2-arm randomized controlled trial was performed. Forty-five women at 22 to 34 weeks of gestation were eligible, whose ritodrine did not sufficientl...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/965060 |
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| author | Yasuyuki Kawagoe Hiroshi Sameshima Tsuyomu Ikenoue Ichiro Yasuhi Tatsuhiko Kawarabayashi |
| author_facet | Yasuyuki Kawagoe Hiroshi Sameshima Tsuyomu Ikenoue Ichiro Yasuhi Tatsuhiko Kawarabayashi |
| author_sort | Yasuyuki Kawagoe |
| collection | DOAJ |
| description | Objectives. We evaluated the efficacy of magnesium sulfate as a second-line tocolysis for 48 hours. Materials and Methods. A multi-institutional, simple 2-arm randomized controlled trial was performed. Forty-five women at 22 to 34 weeks of gestation were eligible, whose ritodrine did not sufficiently inhibit uterine contractions. After excluding 12 women, 33 were randomly assigned to either magnesium alone or combination (ritodrine and magnesium). The treatment was determined as effective if the frequency of uterine contraction was reduced by 30% at 48 hours of the treatment. Results. After magnesium sulfate infusion, 90% prolonged their pregnancy for >48 hours. Combination therapy was effective in 95% (18/19), which was significantly higher than 50% (7/14) for magnesium alone. Conclusion. This randomized trial revealed that combination therapy significantly reduced uterine contractions, suggesting that adjuvant magnesium with ritodrine is recommended, rather than changing into magnesium alone, when uterine contractions are intractable with ritodrine infusion. |
| format | Article |
| id | doaj-art-894539b9d3dd487990e97b226d92d121 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-894539b9d3dd487990e97b226d92d1212025-02-03T05:47:50ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/965060965060Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu IslandYasuyuki Kawagoe0Hiroshi Sameshima1Tsuyomu Ikenoue2Ichiro Yasuhi3Tatsuhiko Kawarabayashi4Department of Obstetrics and Gynecology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology, National Hospital Organization Nagasaki Medical Center, Nagasaki 856-8562, JapanDepartment of Obstetrics and Gynecology, Fukuoka University, Fukuoka 814-0180, JapanObjectives. We evaluated the efficacy of magnesium sulfate as a second-line tocolysis for 48 hours. Materials and Methods. A multi-institutional, simple 2-arm randomized controlled trial was performed. Forty-five women at 22 to 34 weeks of gestation were eligible, whose ritodrine did not sufficiently inhibit uterine contractions. After excluding 12 women, 33 were randomly assigned to either magnesium alone or combination (ritodrine and magnesium). The treatment was determined as effective if the frequency of uterine contraction was reduced by 30% at 48 hours of the treatment. Results. After magnesium sulfate infusion, 90% prolonged their pregnancy for >48 hours. Combination therapy was effective in 95% (18/19), which was significantly higher than 50% (7/14) for magnesium alone. Conclusion. This randomized trial revealed that combination therapy significantly reduced uterine contractions, suggesting that adjuvant magnesium with ritodrine is recommended, rather than changing into magnesium alone, when uterine contractions are intractable with ritodrine infusion.http://dx.doi.org/10.1155/2011/965060 |
| spellingShingle | Yasuyuki Kawagoe Hiroshi Sameshima Tsuyomu Ikenoue Ichiro Yasuhi Tatsuhiko Kawarabayashi Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island Journal of Pregnancy |
| title | Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island |
| title_full | Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island |
| title_fullStr | Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island |
| title_full_unstemmed | Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island |
| title_short | Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island |
| title_sort | magnesium sulfate as a second line tocolytic agent for preterm labor a randomized controlled trial in kyushu island |
| url | http://dx.doi.org/10.1155/2011/965060 |
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