Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion
Carbon-based nanomaterials have been explored as effective adsorbents to remove bilirubin in hemoperfusion therapy. However, developing carbon-based absorbents with both high adsorption capacity and good hemocompatibility remains a challenge in clinical applications. In this study, an efficient adso...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Functional Diamond |
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| Online Access: | http://dx.doi.org/10.1080/26941112.2023.2300475 |
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| author | Futao Wang Xiangyun Zheng Qi Zhao Yuchen Feng Guanyue Gao Dalibor M. Stanković Jinfang Zhi |
| author_facet | Futao Wang Xiangyun Zheng Qi Zhao Yuchen Feng Guanyue Gao Dalibor M. Stanković Jinfang Zhi |
| author_sort | Futao Wang |
| collection | DOAJ |
| description | Carbon-based nanomaterials have been explored as effective adsorbents to remove bilirubin in hemoperfusion therapy. However, developing carbon-based absorbents with both high adsorption capacity and good hemocompatibility remains a challenge in clinical applications. In this study, an efficient adsorbent for bilirubin removal was fabricated by grafting polyaniline (PANI) onto nanodiamonds (NDs). The nanocomposite ND-PANI had negligible effect on the hemolytic activity, confirming its excellent blood compatibility. The adsorption results revealed that the ND-PANI had high adsorption capacities (947 mg/g) and rapid adsorption rate toward bilirubin. Moreover, it exhibited efficient bilirubin adsorption in bovine serum albumin (BSA) solution, indicating its potential for practical application. Additionally, the adsorption kinetics and isotherms were systematically analyzed and modeled, thereby offering insights into the possible adsorption mechanism. Our findings suggest that the ND-PANI could be used as an efficient sorbent for the bilirubin removal, offering a promising avenue for blood purification application. |
| format | Article |
| id | doaj-art-893ec3b4e3c9490c983079f1315fcbb1 |
| institution | DOAJ |
| issn | 2694-1120 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Functional Diamond |
| spelling | doaj-art-893ec3b4e3c9490c983079f1315fcbb12025-08-20T03:14:58ZengTaylor & Francis GroupFunctional Diamond2694-11202024-12-014110.1080/26941112.2023.23004752300475Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusionFutao Wang0Xiangyun Zheng1Qi Zhao2Yuchen Feng3Guanyue Gao4Dalibor M. Stanković5Jinfang Zhi6Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of SciencesKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of SciencesKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of SciencesKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of SciencesKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of SciencesInnovation Center of the Faculty of Chemistry, University of BelgradeKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of SciencesCarbon-based nanomaterials have been explored as effective adsorbents to remove bilirubin in hemoperfusion therapy. However, developing carbon-based absorbents with both high adsorption capacity and good hemocompatibility remains a challenge in clinical applications. In this study, an efficient adsorbent for bilirubin removal was fabricated by grafting polyaniline (PANI) onto nanodiamonds (NDs). The nanocomposite ND-PANI had negligible effect on the hemolytic activity, confirming its excellent blood compatibility. The adsorption results revealed that the ND-PANI had high adsorption capacities (947 mg/g) and rapid adsorption rate toward bilirubin. Moreover, it exhibited efficient bilirubin adsorption in bovine serum albumin (BSA) solution, indicating its potential for practical application. Additionally, the adsorption kinetics and isotherms were systematically analyzed and modeled, thereby offering insights into the possible adsorption mechanism. Our findings suggest that the ND-PANI could be used as an efficient sorbent for the bilirubin removal, offering a promising avenue for blood purification application.http://dx.doi.org/10.1080/26941112.2023.2300475nanodiamondsbilirubinadsorptionhemoperfusion |
| spellingShingle | Futao Wang Xiangyun Zheng Qi Zhao Yuchen Feng Guanyue Gao Dalibor M. Stanković Jinfang Zhi Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion Functional Diamond nanodiamonds bilirubin adsorption hemoperfusion |
| title | Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion |
| title_full | Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion |
| title_fullStr | Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion |
| title_full_unstemmed | Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion |
| title_short | Fabrication of nanodiamonds/polyaniline nanocomposite for bilirubin adsorption in hemoperfusion |
| title_sort | fabrication of nanodiamonds polyaniline nanocomposite for bilirubin adsorption in hemoperfusion |
| topic | nanodiamonds bilirubin adsorption hemoperfusion |
| url | http://dx.doi.org/10.1080/26941112.2023.2300475 |
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