Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke
[Objective] To explore the effects of Sanqitongshu capsule combined with argatroban on neurological deficits and peripheral blood endothelin-1 (ET-1), CD41, CD62P and soluble intercellular adhesion molecule-1 (sICAM-1) expressions in elderly patients with acute ischemic stroke. [Methods] A total of...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of International Journal of Geriatrics
2025-01-01
|
| Series: | Guoji laonian yixue zazhi |
| Subjects: | |
| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.015&lang=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592799434801152 |
|---|---|
| author | Fang Hu Yunping Liu Jia Li Hui Xuan Huijuan Wang Xuehai Lv |
| author_facet | Fang Hu Yunping Liu Jia Li Hui Xuan Huijuan Wang Xuehai Lv |
| author_sort | Fang Hu |
| collection | DOAJ |
| description | [Objective] To explore the effects of Sanqitongshu capsule combined with argatroban on neurological deficits and peripheral blood endothelin-1 (ET-1), CD41, CD62P and soluble intercellular adhesion molecule-1 (sICAM-1) expressions in elderly patients with acute ischemic stroke. [Methods] A total of 106 elderly patients with acute ischemic stroke from Handan Central Hospital were divided into a study group and a control group according to the random number table method, each had 53 cases.Both groups were given basic treatment, the control group was treated with argatroban, the study group was treated with Sanqitongshu capsule on the basis of the control group.Both groups were treated for 7 days.The clinical efficacy, the National Institutes of Health Stroke Scale (NIHSS) score, hemorheology index, the expression levels of ET-1, CD41, CD62P and sICAM-1 in the two groups before and after treatment, and adverse reactions of the two groups were compared. [Results] After treatment, the total effective rate of the study group was significantly higher than that in the control group (P<0.05).The NIHSS score, plasma fibrinogen level, plasma viscosity, erythrocyte aggregation index and the expression levels of ET-1, CD41, CD62P and sICAM-1 in peripheral blood in the two groups were significantly decreased (P<0.05), and these indicators in the study group were significantly lower than those in the control group (P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). [Conclusion] Sanqitongshu capsule combined with argatroban has a significant effect in the treatment of elderly acute ischemic stroke, it can reduce the degree of neurological deficits, and reduce the expressions of ET-1, CD41, CD62P and sICAM-1. |
| format | Article |
| id | doaj-art-893815ef491c4364ba830182e0294fb2 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-893815ef491c4364ba830182e0294fb22025-01-21T02:59:39ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-01-01461737710.3969/j.issn.1674-7593.2025.01.015Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic strokeFang Hu0Yunping Liu1Jia Li2Hui Xuan3Huijuan Wang4Xuehai Lv5Handan Central Hospital, Handan 056000Handan Central Hospital, Handan 056000Handan Second Hospital, Handan 056002Handan Central Hospital, Handan 056000Handan Central Hospital, Handan 056000Handan Central Hospital, Handan 056000[Objective] To explore the effects of Sanqitongshu capsule combined with argatroban on neurological deficits and peripheral blood endothelin-1 (ET-1), CD41, CD62P and soluble intercellular adhesion molecule-1 (sICAM-1) expressions in elderly patients with acute ischemic stroke. [Methods] A total of 106 elderly patients with acute ischemic stroke from Handan Central Hospital were divided into a study group and a control group according to the random number table method, each had 53 cases.Both groups were given basic treatment, the control group was treated with argatroban, the study group was treated with Sanqitongshu capsule on the basis of the control group.Both groups were treated for 7 days.The clinical efficacy, the National Institutes of Health Stroke Scale (NIHSS) score, hemorheology index, the expression levels of ET-1, CD41, CD62P and sICAM-1 in the two groups before and after treatment, and adverse reactions of the two groups were compared. [Results] After treatment, the total effective rate of the study group was significantly higher than that in the control group (P<0.05).The NIHSS score, plasma fibrinogen level, plasma viscosity, erythrocyte aggregation index and the expression levels of ET-1, CD41, CD62P and sICAM-1 in peripheral blood in the two groups were significantly decreased (P<0.05), and these indicators in the study group were significantly lower than those in the control group (P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). [Conclusion] Sanqitongshu capsule combined with argatroban has a significant effect in the treatment of elderly acute ischemic stroke, it can reduce the degree of neurological deficits, and reduce the expressions of ET-1, CD41, CD62P and sICAM-1.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.015&lang=enacute ischemic strokesanqitongshu capsuleargatrobanneurological deficits |
| spellingShingle | Fang Hu Yunping Liu Jia Li Hui Xuan Huijuan Wang Xuehai Lv Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke Guoji laonian yixue zazhi acute ischemic stroke sanqitongshu capsule argatroban neurological deficits |
| title | Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke |
| title_full | Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke |
| title_fullStr | Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke |
| title_full_unstemmed | Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke |
| title_short | Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke |
| title_sort | effect and curative effect of sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke |
| topic | acute ischemic stroke sanqitongshu capsule argatroban neurological deficits |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.015&lang=en |
| work_keys_str_mv | AT fanghu effectandcurativeeffectofsanqitongshucapsulecombinedwithargatrobanonneurologicaldeficitselderlypatientswithacuteischemicstroke AT yunpingliu effectandcurativeeffectofsanqitongshucapsulecombinedwithargatrobanonneurologicaldeficitselderlypatientswithacuteischemicstroke AT jiali effectandcurativeeffectofsanqitongshucapsulecombinedwithargatrobanonneurologicaldeficitselderlypatientswithacuteischemicstroke AT huixuan effectandcurativeeffectofsanqitongshucapsulecombinedwithargatrobanonneurologicaldeficitselderlypatientswithacuteischemicstroke AT huijuanwang effectandcurativeeffectofsanqitongshucapsulecombinedwithargatrobanonneurologicaldeficitselderlypatientswithacuteischemicstroke AT xuehailv effectandcurativeeffectofsanqitongshucapsulecombinedwithargatrobanonneurologicaldeficitselderlypatientswithacuteischemicstroke |