Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors
Objective To investigate the clinicopathological characteristics of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV) with renal involvement and other organs in Inner Mongolia People’s Hospital and to analyze the outcomes and risk factors.Methods Clinical features of 123 cases of...
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Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | LIU Guo-ping WANG Chun-yan XU Li-bin CAO Sai-xia GUO Yan |
| author_facet | LIU Guo-ping WANG Chun-yan XU Li-bin CAO Sai-xia GUO Yan |
| author_sort | LIU Guo-ping |
| collection | DOAJ |
| description | Objective To investigate the clinicopathological characteristics of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV) with renal involvement and other organs in Inner Mongolia People’s Hospital and to analyze the outcomes and risk factors.Methods Clinical features of 123 cases of AAV hospitalized from September 1995 to September 2009 were reviewed retrospectively.According to the ANCA test results,the patients were divided into cytoplastic ANCA positive group(C-ANCA group) and perinuclear ANCA positive group(P-ANCA group).The differences in clinicopathological manifestations,laboratory tests and functional outcomes were observed.The death and renal failure were the end point in the 5 years.Results Of 123 AAV patients,63 were male,and 60 were female(the male and female ratio was 1.05:1).The age ranged from 38-82 years old.82.9%of them(102 cases) were in the range of 50-82 years old(mean 60 ± 22).109 were PANCA positive,and 14 were C-ANCA positive.Renal involvement and lung involvement were similar between C-ANCA group and P-ANCA group.The prevalence of respiratory,gastrointestinal,articular and ophthalmic involvements was higher in P-ANCA group than in C-ANCA group(P<0.05).There was no significant difference in otologic,cutaneous,muscular and neural involvements between two groups.Of the 62 cases receiving renal biopsy,crescent nephritis was found in 30 cases,glomerrular segmental necrosis in 12 cases,mesenteria crescent in 15 cases,and fabric crescent with focal segmental sclerosis in 15 cases.There was no significant difference in mortality and renal failure between two groups.Respiratory failure and multiple organ dysfunctions were relative mortality factors in the analysis of age,sex,types of ANCA,fever,renal failure,respiratory and lung infection.There were significant relationships between clinical terminus with serum creatinine,erythrocyte sediment rate,plasma-albumin and hemoglobin.Logistic regression analysis revealed that serum creatinine level and erythrocyte sediment rate at the baseline were associated with poor outcomes.Conclusions AAV is common in elders and men with multiple organ involvement P-ANCA positive patients are more than C-ANCA patients.The number of organ involvements in P-ANCA group is greater than that in C-ANCA group.The disease spectrum is different in these two groups.Respiratory failure and multiple organ dysfunctions were relative mortality factors. |
| format | Article |
| id | doaj-art-8936f6950c9543e28e7fc33de3252b77 |
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| issn | 1671-2390 |
| language | zho |
| publishDate | 2016-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| spelling | doaj-art-8936f6950c9543e28e7fc33de3252b772025-08-20T02:28:49ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902016-01-0145746157918199Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factorsLIU Guo-pingWANG Chun-yanXU Li-binCAO Sai-xiaGUO YanObjective To investigate the clinicopathological characteristics of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV) with renal involvement and other organs in Inner Mongolia People’s Hospital and to analyze the outcomes and risk factors.Methods Clinical features of 123 cases of AAV hospitalized from September 1995 to September 2009 were reviewed retrospectively.According to the ANCA test results,the patients were divided into cytoplastic ANCA positive group(C-ANCA group) and perinuclear ANCA positive group(P-ANCA group).The differences in clinicopathological manifestations,laboratory tests and functional outcomes were observed.The death and renal failure were the end point in the 5 years.Results Of 123 AAV patients,63 were male,and 60 were female(the male and female ratio was 1.05:1).The age ranged from 38-82 years old.82.9%of them(102 cases) were in the range of 50-82 years old(mean 60 ± 22).109 were PANCA positive,and 14 were C-ANCA positive.Renal involvement and lung involvement were similar between C-ANCA group and P-ANCA group.The prevalence of respiratory,gastrointestinal,articular and ophthalmic involvements was higher in P-ANCA group than in C-ANCA group(P<0.05).There was no significant difference in otologic,cutaneous,muscular and neural involvements between two groups.Of the 62 cases receiving renal biopsy,crescent nephritis was found in 30 cases,glomerrular segmental necrosis in 12 cases,mesenteria crescent in 15 cases,and fabric crescent with focal segmental sclerosis in 15 cases.There was no significant difference in mortality and renal failure between two groups.Respiratory failure and multiple organ dysfunctions were relative mortality factors in the analysis of age,sex,types of ANCA,fever,renal failure,respiratory and lung infection.There were significant relationships between clinical terminus with serum creatinine,erythrocyte sediment rate,plasma-albumin and hemoglobin.Logistic regression analysis revealed that serum creatinine level and erythrocyte sediment rate at the baseline were associated with poor outcomes.Conclusions AAV is common in elders and men with multiple organ involvement P-ANCA positive patients are more than C-ANCA patients.The number of organ involvements in P-ANCA group is greater than that in C-ANCA group.The disease spectrum is different in these two groups.Respiratory failure and multiple organ dysfunctions were relative mortality factors.http://www.lcszb.com/thesisDetails?columnId=57918199&Fpath=home&index=0Primary small vessel vasculitisAntineutrophil cytoplasmic antibodyClinical pathologyRisk factors |
| spellingShingle | LIU Guo-ping WANG Chun-yan XU Li-bin CAO Sai-xia GUO Yan Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors Linchuang shenzangbing zazhi Primary small vessel vasculitis Antineutrophil cytoplasmic antibody Clinical pathology Risk factors |
| title | Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors |
| title_full | Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors |
| title_fullStr | Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors |
| title_full_unstemmed | Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors |
| title_short | Clinicopathologic characteristics of kidney and other organs in ANCA-associated vasculitis patients and outcomes and risk factors |
| title_sort | clinicopathologic characteristics of kidney and other organs in anca associated vasculitis patients and outcomes and risk factors |
| topic | Primary small vessel vasculitis Antineutrophil cytoplasmic antibody Clinical pathology Risk factors |
| url | http://www.lcszb.com/thesisDetails?columnId=57918199&Fpath=home&index=0 |
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