Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review
Background: Extracorporeal membrane oxygenation (ECMO) is a life support in newborns with severe respiratory failure. Our main objective was to evaluate the mortality of patients and define positive and negative predictive factors of survival. Methods: We performed a Strengthening the Reporting of O...
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2024-11-01
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| Online Access: | https://www.mdpi.com/2227-9067/11/12/1441 |
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| author | Raffaele Falsaperla Rosanna Zanai Ausilia Desiree Collotta Vincenzo Sortino Giovanna Vitaliti Carla Cimino Bruna Scalia Marco Simone Vaccalluzzo Michela Spatuzza Grete Francesca Privitera Alfredo Pulvirenti Piero Pavone Martino Ruggieri Andrea Marino Salvatore Agati |
| author_facet | Raffaele Falsaperla Rosanna Zanai Ausilia Desiree Collotta Vincenzo Sortino Giovanna Vitaliti Carla Cimino Bruna Scalia Marco Simone Vaccalluzzo Michela Spatuzza Grete Francesca Privitera Alfredo Pulvirenti Piero Pavone Martino Ruggieri Andrea Marino Salvatore Agati |
| author_sort | Raffaele Falsaperla |
| collection | DOAJ |
| description | Background: Extracorporeal membrane oxygenation (ECMO) is a life support in newborns with severe respiratory failure. Our main objective was to evaluate the mortality of patients and define positive and negative predictive factors of survival. Methods: We performed a Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)-conformed retrospective observational study and a systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our data were analyzed using R (v.4.2.1). We performed survival analysis, correlation analysis, and Fisher’s exact test. The first endpoint was the mortality rate. The second endpoint was to evaluate all factors associated with survival. The third endpoint was focused on complications of ECMO. Results: Our study included 8 patients treated in our centers and 45 patients from the literature review. Survival was 79%. Positive predictive factors of survival were a length of ECMO of less than 10 days and male neonates, while prematurity and the presence of 2 complications were negative predictive factors. Conclusions: ECMO functions as life support, although mortality and morbidity risks are high. |
| format | Article |
| id | doaj-art-89350eec0b6f497aab15aa20da9a44e6 |
| institution | DOAJ |
| issn | 2227-9067 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-89350eec0b6f497aab15aa20da9a44e62025-08-20T02:50:52ZengMDPI AGChildren2227-90672024-11-011112144110.3390/children11121441Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic ReviewRaffaele Falsaperla0Rosanna Zanai1Ausilia Desiree Collotta2Vincenzo Sortino3Giovanna Vitaliti4Carla Cimino5Bruna Scalia6Marco Simone Vaccalluzzo7Michela Spatuzza8Grete Francesca Privitera9Alfredo Pulvirenti10Piero Pavone11Martino Ruggieri12Andrea Marino13Salvatore Agati14Neonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico “G. Rodolico-San Marco”, San Marco Hospital, University of Catania, 95121 Catania, ItalyCardiovascular Department, Mediterranean Pediatric Cardiology Center, Bambino Gesù Children’s Hospital, 98035 Taormina, ItalyPediatrics and Pediatric Emergency Operative Unit, Azienda Ospedaliero Universitaria Policlinico “G. Rodolico-San Marco”, San Marco Hospital, University of Catania, 95121 Catania, ItalyPediatrics and Pediatric Emergency Operative Unit, Azienda Ospedaliero Universitaria Policlinico “G. Rodolico-San Marco”, San Marco Hospital, University of Catania, 95121 Catania, ItalyPediatrics and Pediatric Emergency Operative Unit, Azienda Ospedaliero Universitaria Policlinico “G. Rodolico-San Marco”, San Marco Hospital, University of Catania, 95121 Catania, ItalyNeonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico “G. Rodolico-San Marco”, San Marco Hospital, University of Catania, 95121 Catania, ItalyNeonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico “G. Rodolico-San Marco”, San Marco Hospital, University of Catania, 95121 Catania, ItalyDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics, A.O.U. Policlinico Rodolico-San Marco, University of Catania, 95123 Catania, ItalyInstitute for Biomedical Research and Innovation (IRIB), National Research Council, 98164 Catania, ItalyBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU Policlinico “G. Rodolico-San Marco”, University of Catania, 95123 Catania, ItalyUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU Policlinico “G. Rodolico-San Marco”, University of Catania, 95123 Catania, ItalyUnit of Infectious Disease, Department of Clinical and Experimental Medicine, AOU Garibaldi, University of Catania, 95123 Catania, ItalyCardiovascular Department, Mediterranean Pediatric Cardiology Center, Bambino Gesù Children’s Hospital, 98035 Taormina, ItalyBackground: Extracorporeal membrane oxygenation (ECMO) is a life support in newborns with severe respiratory failure. Our main objective was to evaluate the mortality of patients and define positive and negative predictive factors of survival. Methods: We performed a Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)-conformed retrospective observational study and a systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our data were analyzed using R (v.4.2.1). We performed survival analysis, correlation analysis, and Fisher’s exact test. The first endpoint was the mortality rate. The second endpoint was to evaluate all factors associated with survival. The third endpoint was focused on complications of ECMO. Results: Our study included 8 patients treated in our centers and 45 patients from the literature review. Survival was 79%. Positive predictive factors of survival were a length of ECMO of less than 10 days and male neonates, while prematurity and the presence of 2 complications were negative predictive factors. Conclusions: ECMO functions as life support, although mortality and morbidity risks are high.https://www.mdpi.com/2227-9067/11/12/1441extracorporeal membrane oxygenation∙neonatalECMO respiratory failurelife-support |
| spellingShingle | Raffaele Falsaperla Rosanna Zanai Ausilia Desiree Collotta Vincenzo Sortino Giovanna Vitaliti Carla Cimino Bruna Scalia Marco Simone Vaccalluzzo Michela Spatuzza Grete Francesca Privitera Alfredo Pulvirenti Piero Pavone Martino Ruggieri Andrea Marino Salvatore Agati Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review Children extracorporeal membrane oxygenation∙neonatal ECMO respiratory failure life-support |
| title | Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review |
| title_full | Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review |
| title_fullStr | Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review |
| title_full_unstemmed | Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review |
| title_short | Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review |
| title_sort | extracorporeal membrane oxygenation as life support in neonatal respiratory failure a single center cohort study and a systematic review |
| topic | extracorporeal membrane oxygenation∙neonatal ECMO respiratory failure life-support |
| url | https://www.mdpi.com/2227-9067/11/12/1441 |
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