Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation

Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation

Objectives: This study aimed to examine the influence of matrix stiffness on osteogenic differentiation via epigenetic mechanisms in human periodontal ligament stem cells (hPDLSCs), with implications for understanding orthodontic tooth movement. Materials and Methods: hPDLSCs were cultured on substr...

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Bibliographic Details
Main Authors: Rong Ding, Chen Chen, Ling Wang, Yijie Wang, Zhen Chai, Siyu He, Qianqian Zhang, Shuli Cheng, Rui Zou
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:International Dental Journal
Subjects:
Matrix stiffness
DNA methylation
DNA methyltransferase
hPDLSCs
Osteogenic differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0020653925000619
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