Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis
Stable angina is a prevalent heart disease which can be defined as a clinical syndrome of stable coronary artery disease (CAD) that refers to the presence of myocardial ischemia. Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is an important biomarker of atherosclerosis progression through pro-i...
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College of Pharmacy / Mustansiriyah University
2025-01-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1121 |
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| author | Aseel Ghassan Daoud Wassan Abdul Kareem Abbas Ahmed Yousif Hasan Maha N. Abu Hajleh |
| author_facet | Aseel Ghassan Daoud Wassan Abdul Kareem Abbas Ahmed Yousif Hasan Maha N. Abu Hajleh |
| author_sort | Aseel Ghassan Daoud |
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Stable angina is a prevalent heart disease which can be defined as a clinical syndrome of stable coronary artery disease (CAD) that refers to the presence of myocardial ischemia. Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is an important biomarker of atherosclerosis progression through pro-inflammatory and anti-inflammatory effects.
Objective: The aim was to detect the role of Lp-PLA2 in the diagnosis of patients with stable angina and normal left ventricular ejection fraction (LVEF).
Patients and methods: The study design was a case-control study. 90 males and females (age 40-76 years) who were presented with chest pain were enrolled in the study, all were subjected to echocardiography, ECG and coronary angiography by the cardiologist. Besides, patient’s questionnaire and biochemical analysis were also used. According to the angiography, they were divided into two groups: 60 patients and 30 as a control group. Levels of Lp-PLA2, total cholesterol, triglycerides (TG), high density lipoprotein-Cholesterol (HDL-C), very low density lipoprotein-Cholesterol (VLDL-C) and low density lipoprotein-Cholesterol (LDL-C) in serum were assessed. The biplane M mode method was used to measure left ventricular ejection fraction (LVEF).
Result: It was detected that Lp-PLA2 serum levels were significantly higher in the patients than in the control, (P≤0.01). ROC analysis showed that Lp-PLA2 had specificity of 100% and sensitivity 100%.
Conclusion: Measurement of Lp-PLA2 can be applied as an excellent biomarker in the diagnosis of patients with stable angina and normal LV ejection fraction.
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| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
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| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj-art-892fb4922788449ba027f66e08b498f62025-01-24T13:47:27ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2025-01-0125110.32947/ajps.v25i1.1121Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography DiagnosisAseel Ghassan Daoud0Wassan Abdul Kareem Abbas1Ahmed Yousif Hasan2Maha N. Abu Hajleh3Department of Clinical Laboratory Sciences, College of Pharmacy, Mustansiriyah University, Baghdad, IraqDepartment of Clinical Laboratory Sciences, College of Pharmacy, Mustansiriyah University, Baghdad, IraqIraqi Center for Heart Diseases, Medical City Teaching Hospital, Baghdad, IraqDepartment of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan Stable angina is a prevalent heart disease which can be defined as a clinical syndrome of stable coronary artery disease (CAD) that refers to the presence of myocardial ischemia. Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is an important biomarker of atherosclerosis progression through pro-inflammatory and anti-inflammatory effects. Objective: The aim was to detect the role of Lp-PLA2 in the diagnosis of patients with stable angina and normal left ventricular ejection fraction (LVEF). Patients and methods: The study design was a case-control study. 90 males and females (age 40-76 years) who were presented with chest pain were enrolled in the study, all were subjected to echocardiography, ECG and coronary angiography by the cardiologist. Besides, patient’s questionnaire and biochemical analysis were also used. According to the angiography, they were divided into two groups: 60 patients and 30 as a control group. Levels of Lp-PLA2, total cholesterol, triglycerides (TG), high density lipoprotein-Cholesterol (HDL-C), very low density lipoprotein-Cholesterol (VLDL-C) and low density lipoprotein-Cholesterol (LDL-C) in serum were assessed. The biplane M mode method was used to measure left ventricular ejection fraction (LVEF). Result: It was detected that Lp-PLA2 serum levels were significantly higher in the patients than in the control, (P≤0.01). ROC analysis showed that Lp-PLA2 had specificity of 100% and sensitivity 100%. Conclusion: Measurement of Lp-PLA2 can be applied as an excellent biomarker in the diagnosis of patients with stable angina and normal LV ejection fraction. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1121Coronary artery diseasediagnosisleft ventricular ejection fractionlipoprotein-associated phospholipase A2stable angina |
| spellingShingle | Aseel Ghassan Daoud Wassan Abdul Kareem Abbas Ahmed Yousif Hasan Maha N. Abu Hajleh Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis Al-Mustansiriyah Journal of Pharmaceutical Sciences Coronary artery disease diagnosis left ventricular ejection fraction lipoprotein-associated phospholipase A2 stable angina |
| title | Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis |
| title_full | Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis |
| title_fullStr | Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis |
| title_full_unstemmed | Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis |
| title_short | Exploring Lipoprotein-Associated Phospholipase A2 Levels in Iraqi Patients with Stable Angina: Insights from Coronary Angiography Diagnosis |
| title_sort | exploring lipoprotein associated phospholipase a2 levels in iraqi patients with stable angina insights from coronary angiography diagnosis |
| topic | Coronary artery disease diagnosis left ventricular ejection fraction lipoprotein-associated phospholipase A2 stable angina |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1121 |
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