New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson’s disease

New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson’s disease

Introduction: One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant and neuroprotective effects in some neurodegenerative diseases, including PD. C...

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Main Authors: Silvana-Yanina Romero-Zerbo, Nadia Valverde, Silvia Claros, Pablo Zamorano-Gonzalez, Federica Boraldi, Francesco-Demetrio Lofaro, Estrella Lara, Jose Pavia, Maria Garcia-Fernandez, Belen Gago, Elisa Martin-Montañez
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Advanced Research
Subjects:
Parkinsońs disease
IGF-II
Neuroprotection
Mitochondria
Cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224000493
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