The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study
Abstract Background The coronavirus disease‐2019 (COVID‐19) has become a worldwide health issue with widespread hospitalization and dependence on the intensive care unit (ICU). Vitamin D has a key role in modulating immune cells and modulating the inflammatory responses. This study aimed to investig...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.844 |
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| author | Maryam Gholamalizadeh Faezeh Rabbani Mina Ahmadzadeh Azadeh Hajipour Hayehe Musavi Khadijeh Abbasi Mobarakeh Zahra Salimi Bojlul Bahar Zahra Mahmoodi Somayeh Gholami Samaneh Mirzaei Dahka Saeid Doaei Mokammad Esmail Akbari |
| author_facet | Maryam Gholamalizadeh Faezeh Rabbani Mina Ahmadzadeh Azadeh Hajipour Hayehe Musavi Khadijeh Abbasi Mobarakeh Zahra Salimi Bojlul Bahar Zahra Mahmoodi Somayeh Gholami Samaneh Mirzaei Dahka Saeid Doaei Mokammad Esmail Akbari |
| author_sort | Maryam Gholamalizadeh |
| collection | DOAJ |
| description | Abstract Background The coronavirus disease‐2019 (COVID‐19) has become a worldwide health issue with widespread hospitalization and dependence on the intensive care unit (ICU). Vitamin D has a key role in modulating immune cells and modulating the inflammatory responses. This study aimed to investigate the association of vitamin D supplementation with inflammatory, biochemical, and mortality indices in critically ill patients with COVID‐19. Methods This case‐control study was conducted on critically ill COVID‐19 patients hospitalized in the ICU including the survived >30 day patients as the case group and dead patients as the control group. The status of vitamin D supplementation and inflammatory and biochemical indices of the patients were retrieved from the medical records. Logistic regression method was used to assess the association between 30 days survival and vitamin D supplement intake. Results Compared to the group of COVID‐19 patients who died in <30 day, the survived patients had a lower eosinophile level (2.2 ± 0.5 vs. 6 ± 0.0, p < .001) and higher vitamin D supplementation duration (9 ± 4.4 vs. 3.3 ± 1.9 day, p = .001). Vitamin D supplementation had a positive association with survival in COVID‐19 patients (OR: 1.98, 95% CI: 1.15−3.40, p < .05). The association remained significant after adjustments fot age, sex, underlying diseases, and smoking. Conclusion Vitamin D supplementation in critically ill patients with COVID‐19 has the potential to increase survivability within the first 30 days of hospitalization. |
| format | Article |
| id | doaj-art-8928131b2bbd4b44894b8d481c53495a |
| institution | DOAJ |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-8928131b2bbd4b44894b8d481c53495a2025-08-20T03:06:26ZengWileyImmunity, Inflammation and Disease2050-45272023-04-01114n/an/a10.1002/iid3.844The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control studyMaryam Gholamalizadeh0Faezeh Rabbani1Mina Ahmadzadeh2Azadeh Hajipour3Hayehe Musavi4Khadijeh Abbasi Mobarakeh5Zahra Salimi6Bojlul Bahar7Zahra Mahmoodi8Somayeh Gholami9Samaneh Mirzaei Dahka10Saeid Doaei11Mokammad Esmail Akbari12Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran IranDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center Shahid Sadoughi University of Medical Sciences Yazd IranDepartment of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran IranSchool of Health Qazvin University of Medical Sciences Qazvin IranTabriz University of Medical Sciences Rasht IranDepartment of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science Isfahan University of Medical Sciences Isfahan IranNutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz IranNutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences University of Central Lancashire Preston UKDepartment of Nutrition, Science and Research Branch Islamic Azad University Tehran IranRazi Hospital, Guilan University of Medical Sciences Rasht IranSchool of Nursing and Midwifery, Guilan University of Medical Sciences Rasht IranDepartment of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran IranCancer Research Center Shahid Beheshti University of Medical Sciences Tehran IranAbstract Background The coronavirus disease‐2019 (COVID‐19) has become a worldwide health issue with widespread hospitalization and dependence on the intensive care unit (ICU). Vitamin D has a key role in modulating immune cells and modulating the inflammatory responses. This study aimed to investigate the association of vitamin D supplementation with inflammatory, biochemical, and mortality indices in critically ill patients with COVID‐19. Methods This case‐control study was conducted on critically ill COVID‐19 patients hospitalized in the ICU including the survived >30 day patients as the case group and dead patients as the control group. The status of vitamin D supplementation and inflammatory and biochemical indices of the patients were retrieved from the medical records. Logistic regression method was used to assess the association between 30 days survival and vitamin D supplement intake. Results Compared to the group of COVID‐19 patients who died in <30 day, the survived patients had a lower eosinophile level (2.2 ± 0.5 vs. 6 ± 0.0, p < .001) and higher vitamin D supplementation duration (9 ± 4.4 vs. 3.3 ± 1.9 day, p = .001). Vitamin D supplementation had a positive association with survival in COVID‐19 patients (OR: 1.98, 95% CI: 1.15−3.40, p < .05). The association remained significant after adjustments fot age, sex, underlying diseases, and smoking. Conclusion Vitamin D supplementation in critically ill patients with COVID‐19 has the potential to increase survivability within the first 30 days of hospitalization.https://doi.org/10.1002/iid3.844Covid‐19critical ill patientvitamin Dsurvivalcritical ill patientvitamin D survival |
| spellingShingle | Maryam Gholamalizadeh Faezeh Rabbani Mina Ahmadzadeh Azadeh Hajipour Hayehe Musavi Khadijeh Abbasi Mobarakeh Zahra Salimi Bojlul Bahar Zahra Mahmoodi Somayeh Gholami Samaneh Mirzaei Dahka Saeid Doaei Mokammad Esmail Akbari The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study Immunity, Inflammation and Disease Covid‐19 critical ill patientvitamin D survivalcritical ill patient vitamin D survival |
| title | The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study |
| title_full | The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study |
| title_fullStr | The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study |
| title_full_unstemmed | The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study |
| title_short | The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study |
| title_sort | association between vitamin d intake with inflammatory and biochemical indices and mortality in critically ill patients with covid 19 a case control study |
| topic | Covid‐19 critical ill patientvitamin D survivalcritical ill patient vitamin D survival |
| url | https://doi.org/10.1002/iid3.844 |
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