Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies
Background: Vitamin B12 (VB12) is a water-soluble vitamin, deficiency of which causes an extensive heterogeneous spectrum of neurological symptoms including vision disturbances, paresthesia, tremor, and seizure. The aim of this investigation is to determine the effect of serum VB12 levels on pediatr...
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Tabriz University of Medical Sciences
2025-04-01
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| Series: | Pharmaceutical Sciences |
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| Online Access: | https://ps.tbzmed.ac.ir/PDF/ps-31-117.pdf |
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| author | Navid Sherafati Hamid Abbasi Sama Rahnemayan Elahe Abdi Bastami Sepehr Khosravi Kiarash Tajernarenj Sarvin Sanaie |
| author_facet | Navid Sherafati Hamid Abbasi Sama Rahnemayan Elahe Abdi Bastami Sepehr Khosravi Kiarash Tajernarenj Sarvin Sanaie |
| author_sort | Navid Sherafati |
| collection | DOAJ |
| description | Background: Vitamin B12 (VB12) is a water-soluble vitamin, deficiency of which causes an extensive heterogeneous spectrum of neurological symptoms including vision disturbances, paresthesia, tremor, and seizure. The aim of this investigation is to determine the effect of serum VB12 levels on pediatric patients with febrile seizure (FS). Methods: In this meta-analysis, case-control studies that evaluated the effect of serum VB12 levels in pediatric patients with FS were included. Web of Science, PubMed, Scopus, and Google Scholar were searched until August 13, 2024. The PICO criteria for this meta-analysis were as follows: Population/Patients (P: pediatric patients with febrile seizures); Issue of interest (I: serum levels of VB12); Comparison (C: control); Outcome (O: occurrence of febrile seizure). Quality assessment was assessed according to the Newcastle-Ottawa Scale (NOS) tool for case-control studies. The outcome assessment scales, study groups, and serum VB12 levels were extracted. Results: Of 435 initial articles, eventually 6 studies remained in the meta-analysis. Existing evidence indicated that serum VB12 concentrations were insignificantly lower in FS patients than controls (WMD= -1.09 pg/ml; 95% CI: -2.23, 0.04; P= 0.06), although a significant between-study heterogeneity was observed (I2 = 98.10%, P< 0.001). Conclusion: The results of our study pointed out that there is low serum VB12 concentrations in FS patients compared with controls. Despite the fact, one of the best ways to prevent FS in children can be VB12 supplementation and proper diet therapy. |
| format | Article |
| id | doaj-art-8924c94fb7cc44eebce5733f519880fb |
| institution | OA Journals |
| issn | 2383-2886 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical Sciences |
| spelling | doaj-art-8924c94fb7cc44eebce5733f519880fb2025-08-20T02:36:58ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862025-04-0131211712610.34172/PS.024.40508ps-40508Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control StudiesNavid Sherafati0Hamid Abbasi1Sama Rahnemayan2Elahe Abdi Bastami3Sepehr Khosravi4Kiarash Tajernarenj5Sarvin Sanaie6Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran.Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Neurosciences Research Center (NSRC), Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.Isfahan Neurosciences Research Center, Isfahan University of Medical sciences, Isfahan, Iran.Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Neurosciences Research Center (NSRC), Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.Background: Vitamin B12 (VB12) is a water-soluble vitamin, deficiency of which causes an extensive heterogeneous spectrum of neurological symptoms including vision disturbances, paresthesia, tremor, and seizure. The aim of this investigation is to determine the effect of serum VB12 levels on pediatric patients with febrile seizure (FS). Methods: In this meta-analysis, case-control studies that evaluated the effect of serum VB12 levels in pediatric patients with FS were included. Web of Science, PubMed, Scopus, and Google Scholar were searched until August 13, 2024. The PICO criteria for this meta-analysis were as follows: Population/Patients (P: pediatric patients with febrile seizures); Issue of interest (I: serum levels of VB12); Comparison (C: control); Outcome (O: occurrence of febrile seizure). Quality assessment was assessed according to the Newcastle-Ottawa Scale (NOS) tool for case-control studies. The outcome assessment scales, study groups, and serum VB12 levels were extracted. Results: Of 435 initial articles, eventually 6 studies remained in the meta-analysis. Existing evidence indicated that serum VB12 concentrations were insignificantly lower in FS patients than controls (WMD= -1.09 pg/ml; 95% CI: -2.23, 0.04; P= 0.06), although a significant between-study heterogeneity was observed (I2 = 98.10%, P< 0.001). Conclusion: The results of our study pointed out that there is low serum VB12 concentrations in FS patients compared with controls. Despite the fact, one of the best ways to prevent FS in children can be VB12 supplementation and proper diet therapy.https://ps.tbzmed.ac.ir/PDF/ps-31-117.pdfchildrenfebrile seizuresystematic reviewvitamin b12 |
| spellingShingle | Navid Sherafati Hamid Abbasi Sama Rahnemayan Elahe Abdi Bastami Sepehr Khosravi Kiarash Tajernarenj Sarvin Sanaie Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies Pharmaceutical Sciences children febrile seizure systematic review vitamin b12 |
| title | Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies |
| title_full | Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies |
| title_fullStr | Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies |
| title_full_unstemmed | Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies |
| title_short | Exploring the Effect of Vitamin B12 on Febrile Seizures in Children: A Systematic Review and Meta-Analysis of Case-Control Studies |
| title_sort | exploring the effect of vitamin b12 on febrile seizures in children a systematic review and meta analysis of case control studies |
| topic | children febrile seizure systematic review vitamin b12 |
| url | https://ps.tbzmed.ac.ir/PDF/ps-31-117.pdf |
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