Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC
Abstract Cancer is a complex health issue that today’s medical science is dealing with, which has a mortality rate that is almost identical to that of cardiac disorders. Because of the adverse effects of the majority of the medications used in its therapy, managing it remains a major concern despite...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87654-9 |
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| author | Iqra Riaz Yamin Bibi Muhammad Arshad Muhammad Sheeraz Ahmad Manzer H. Siddiqui Yawen Zeng Abdul Qayyum |
| author_facet | Iqra Riaz Yamin Bibi Muhammad Arshad Muhammad Sheeraz Ahmad Manzer H. Siddiqui Yawen Zeng Abdul Qayyum |
| author_sort | Iqra Riaz |
| collection | DOAJ |
| description | Abstract Cancer is a complex health issue that today’s medical science is dealing with, which has a mortality rate that is almost identical to that of cardiac disorders. Because of the adverse effects of the majority of the medications used in its therapy, managing it remains a major concern despite the availability of numerous remedies. This article attempts to contribute to the scientific developments in the Solanaceae family’s anti-cancer field. Thus, this study consisted of isolating β-amyrin, cedryl acetate, lupeol, and 2-pentadecanone, 6,10,14-trimethyl from Cestrum aurantiacum to determine the anti-tumor activity. The plant material was dried, pulverized, and small-scale extraction was done. Brine shrimps, cell lines (A549, Hela, HEPG), and Caenorhabditis elegans were used initially to examine three solanaceous plant extracts (Solanum villosum (SV), Cestrum aurantiacum (CA), and Brugmansia suaveolens (BS)). The best results were shown by ethanol extract of Cestrum aurantiacum that why large-scale extraction and GCMS of this extract were done. The antitumor potential can be explained by the presence of β-amyrin, cedryl acetate, lupeol, and 2-pentadecanone, 6,10,14-trimethyl. |
| format | Article |
| id | doaj-art-891e78a0f1504ee5aa3e56f05c3eb830 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-891e78a0f1504ee5aa3e56f05c3eb8302025-02-09T12:35:18ZengNature PortfolioScientific Reports2045-23222025-02-0115111410.1038/s41598-025-87654-9Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLCIqra Riaz0Yamin Bibi1Muhammad Arshad2Muhammad Sheeraz Ahmad3Manzer H. Siddiqui4Yawen Zeng5Abdul Qayyum6Department of Botany, PMAS-Arid Agriculture University RawalpindiDepartment of Botany, PMAS-Arid Agriculture University RawalpindiDepartment of Botany, PMAS-Arid Agriculture University RawalpindiUniversity Institute of Biochemistry and Biotechnology, PMAS-Arid Agriculture University RawalpindiDepartment of Botany and Microbiology, College of Science, King Saud UniversityBiotechnology and Germplasm Resources Institute, Agricultural Biotechnology Key Laboratory of Yunnan Province/Key Laboratory of the Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Yunnan Academy of Agricultural SciencesDepartment of Agronomy, The University of HaripurAbstract Cancer is a complex health issue that today’s medical science is dealing with, which has a mortality rate that is almost identical to that of cardiac disorders. Because of the adverse effects of the majority of the medications used in its therapy, managing it remains a major concern despite the availability of numerous remedies. This article attempts to contribute to the scientific developments in the Solanaceae family’s anti-cancer field. Thus, this study consisted of isolating β-amyrin, cedryl acetate, lupeol, and 2-pentadecanone, 6,10,14-trimethyl from Cestrum aurantiacum to determine the anti-tumor activity. The plant material was dried, pulverized, and small-scale extraction was done. Brine shrimps, cell lines (A549, Hela, HEPG), and Caenorhabditis elegans were used initially to examine three solanaceous plant extracts (Solanum villosum (SV), Cestrum aurantiacum (CA), and Brugmansia suaveolens (BS)). The best results were shown by ethanol extract of Cestrum aurantiacum that why large-scale extraction and GCMS of this extract were done. The antitumor potential can be explained by the presence of β-amyrin, cedryl acetate, lupeol, and 2-pentadecanone, 6,10,14-trimethyl.https://doi.org/10.1038/s41598-025-87654-9CancerCestrum aurantiacumGCMSLupeol |
| spellingShingle | Iqra Riaz Yamin Bibi Muhammad Arshad Muhammad Sheeraz Ahmad Manzer H. Siddiqui Yawen Zeng Abdul Qayyum Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC Scientific Reports Cancer Cestrum aurantiacum GCMS Lupeol |
| title | Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC |
| title_full | Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC |
| title_fullStr | Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC |
| title_full_unstemmed | Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC |
| title_short | Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC |
| title_sort | unravelling anti cancer properties of solanaceous extracts using gc ms and hplc |
| topic | Cancer Cestrum aurantiacum GCMS Lupeol |
| url | https://doi.org/10.1038/s41598-025-87654-9 |
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