Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study
IntroductionSaliva acts as a natural buffer, neutralizing the acids produced by bacterial metabolism. Maintaining salivary pH in a range close to neutrality is essential for enamel remineralization processes. This study aimed to evaluate and compare the effect of different concentrations and formula...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1620432/full |
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| author | Vilma Mamani-Cori Talia Paola Calcina-Asillo Marleny Chino-Mamani Yang Rodrigo Mendoza-Quispe Sidgar Orlando Yucra-Sardón Heber Isac Arbildo-Vega Heber Isac Arbildo-Vega Tania Carola Padilla-Cáceres Betsy Quispe-Quispe Franz Tito Coronel-Zubiate |
| author_facet | Vilma Mamani-Cori Talia Paola Calcina-Asillo Marleny Chino-Mamani Yang Rodrigo Mendoza-Quispe Sidgar Orlando Yucra-Sardón Heber Isac Arbildo-Vega Heber Isac Arbildo-Vega Tania Carola Padilla-Cáceres Betsy Quispe-Quispe Franz Tito Coronel-Zubiate |
| author_sort | Vilma Mamani-Cori |
| collection | DOAJ |
| description | IntroductionSaliva acts as a natural buffer, neutralizing the acids produced by bacterial metabolism. Maintaining salivary pH in a range close to neutrality is essential for enamel remineralization processes. This study aimed to evaluate and compare the effect of different concentrations and formulations of topical fluoride on the regulation of salivary pH in schoolchildren from the Altiplano region of Peru.MethodA quantitative, longitudinal, double-blind, randomized experimental design was employed. A total of 200 children aged 6–12 years who voluntarily agreed to participate were randomly and equally distributed into four study groups. To ensure homogeneous assignment, sociodemographic variables (sex, family type, age, number of siblings, and frequency of daily brushing) and clinical variables (caries severity and oral hygiene level) were controlled. Data were analyzed using SPSS version 25.0. The Shapiro–Wilk test assessed normality (p < 0.05), while Kruskal–Wallis test was used for between-group comparisons and the Friedman test for intragroup comparisons.ResultsIntragroup analysis revealed statistically differences in salivary pH at initial, post-brushing, 10, 30, 60 min and 24-hours measurements across all groups (Friedman's Test; p < 0.001). Between-group comparisons also showed significant differences in salivary pH at 10, 30, 60 min, and at 24 and 48 h (Kruskal–Wallis test; p < 0.05).ConclusionIn conclusion, the 5% fluoride varnish and fluoride gels (1.23% and 2%) demonstrated greater efficacy in regulating salivary pH, especially during the initial hours following application. |
| format | Article |
| id | doaj-art-891b469ea5fa4617a48df80690d3897c |
| institution | Kabale University |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oral Health |
| spelling | doaj-art-891b469ea5fa4617a48df80690d3897c2025-08-20T03:36:37ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-06-01610.3389/froh.2025.16204321620432Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal studyVilma Mamani-Cori0Talia Paola Calcina-Asillo1Marleny Chino-Mamani2Yang Rodrigo Mendoza-Quispe3Sidgar Orlando Yucra-Sardón4Heber Isac Arbildo-Vega5Heber Isac Arbildo-Vega6Tania Carola Padilla-Cáceres7Betsy Quispe-Quispe8Franz Tito Coronel-Zubiate9Department of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of General Dentistry, Dentistry School, San Martín de Porres University, Chiclayo, PeruDepartment of Human Medicine, School of Human Medicine, San Martín de Porres University, Chiclayo, PeruDepartment of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of General Dentistry, Dentistry School, University of the Altiplano, Puno, PeruDepartment of Health Sciences, Stomatologist School, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, PeruIntroductionSaliva acts as a natural buffer, neutralizing the acids produced by bacterial metabolism. Maintaining salivary pH in a range close to neutrality is essential for enamel remineralization processes. This study aimed to evaluate and compare the effect of different concentrations and formulations of topical fluoride on the regulation of salivary pH in schoolchildren from the Altiplano region of Peru.MethodA quantitative, longitudinal, double-blind, randomized experimental design was employed. A total of 200 children aged 6–12 years who voluntarily agreed to participate were randomly and equally distributed into four study groups. To ensure homogeneous assignment, sociodemographic variables (sex, family type, age, number of siblings, and frequency of daily brushing) and clinical variables (caries severity and oral hygiene level) were controlled. Data were analyzed using SPSS version 25.0. The Shapiro–Wilk test assessed normality (p < 0.05), while Kruskal–Wallis test was used for between-group comparisons and the Friedman test for intragroup comparisons.ResultsIntragroup analysis revealed statistically differences in salivary pH at initial, post-brushing, 10, 30, 60 min and 24-hours measurements across all groups (Friedman's Test; p < 0.001). Between-group comparisons also showed significant differences in salivary pH at 10, 30, 60 min, and at 24 and 48 h (Kruskal–Wallis test; p < 0.05).ConclusionIn conclusion, the 5% fluoride varnish and fluoride gels (1.23% and 2%) demonstrated greater efficacy in regulating salivary pH, especially during the initial hours following application.https://www.frontiersin.org/articles/10.3389/froh.2025.1620432/fullcariostatic agentsgelssalivasodium fluoridefluoridestopical |
| spellingShingle | Vilma Mamani-Cori Talia Paola Calcina-Asillo Marleny Chino-Mamani Yang Rodrigo Mendoza-Quispe Sidgar Orlando Yucra-Sardón Heber Isac Arbildo-Vega Heber Isac Arbildo-Vega Tania Carola Padilla-Cáceres Betsy Quispe-Quispe Franz Tito Coronel-Zubiate Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study Frontiers in Oral Health cariostatic agents gels saliva sodium fluoride fluorides topical |
| title | Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study |
| title_full | Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study |
| title_fullStr | Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study |
| title_full_unstemmed | Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study |
| title_short | Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study |
| title_sort | topical fluoride and regulation of salivary ph in peruvian altiplano schoolchildren a comparative longitudinal study |
| topic | cariostatic agents gels saliva sodium fluoride fluorides topical |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1620432/full |
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