Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study
Abstract Backgrounds We aimed to test whether the prediction of presurgical metabolic syndrome for postsurgical survival outcomes of gastric cancer hinges upon cigarette smoking status. Methods This study is a part of the ongoing Fujian prospective investigation of cancer (FIESTA) study. Patients wi...
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| Format: | Article |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.5116 |
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| author | Xinran Zhang Dan Hu Xiangling Deng Jinxiu Lin Xiongwei Zheng Feng Peng Fanqiang Meng Wenquan Niu |
| author_facet | Xinran Zhang Dan Hu Xiangling Deng Jinxiu Lin Xiongwei Zheng Feng Peng Fanqiang Meng Wenquan Niu |
| author_sort | Xinran Zhang |
| collection | DOAJ |
| description | Abstract Backgrounds We aimed to test whether the prediction of presurgical metabolic syndrome for postsurgical survival outcomes of gastric cancer hinges upon cigarette smoking status. Methods This study is a part of the ongoing Fujian prospective investigation of cancer (FIESTA) study. Patients with gastric cancer received radical resection of primary gastric cancer between January 2000 and December 2010, with the latest follow‐up ended in December 2015. The 1:1 propensity score matching analysis was adopted to balance confounders between smokers and never‐smokers. Effect‐size estimates are expressed as hazard ratio (HR) with 95% confidence interval (CI). Model performance was evaluated using the Hosmer and Lemeshow test and 10‐fold cross‐validated area under the receiver operating characteristic curve (AUROC). Statistical analyses were completed with SAS software (v9.4). Results Total 2779 patients with gastric cancer were analyzed, including 2223 smokers and 556 never‐smokers. Median follow‐up time was 45.6 months. Cigarette smoking was not associated with postsurgical survival differences. Presurgical metabolic syndrome complication was significantly associated with increased gastric cancer‐specific mortality in smokers (HR [95% CI]: 2.73 [1.53–4.89], p < 0.001), but not in never‐smokers. Relative excess risk due to interaction was estimated to be 2.43 (95% CI: 0.40–4.45). After constructing a risk assessment score, one unit increment was associated with 10% reduced risk of gastric cancer‐specific mortality (HR [95% CI]: 0.90 [0.88–0.91], p < 0.001), with 10‐fold cross‐validated AUROC being 0.82 (95% CI: 0.74–0.92). Conclusions Our findings showed that the prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality was more evident in smokers. Practically, this study provides evidence base for future personalized prediction and helped risk‐stratify gastric cancer patients who might experience serious postsurgical consequences. |
| format | Article |
| id | doaj-art-8918095a74d3406d82ae16b8f0fe2c84 |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Wiley |
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| series | Cancer Medicine |
| spelling | doaj-art-8918095a74d3406d82ae16b8f0fe2c842025-08-20T02:23:32ZengWileyCancer Medicine2045-76342023-02-011233419343210.1002/cam4.5116Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA studyXinran Zhang0Dan Hu1Xiangling Deng2Jinxiu Lin3Xiongwei Zheng4Feng Peng5Fanqiang Meng6Wenquan Niu7Institute of Clinical Medical Sciences, China‐Japan Friendship Hospital Beijing ChinaDepartment of Pathology Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Fuzhou ChinaInstitute of Clinical Medical Sciences, China‐Japan Friendship Hospital Beijing ChinaDepartment of Cardiology First Affiliated Hospital of Fujian Medical University Fuzhou ChinaDepartment of Pathology Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Fuzhou ChinaDepartment of Cardiology First Affiliated Hospital of Fujian Medical University Fuzhou ChinaDepartment of General Surgery China‐Japan Friendship Hospital Beijing ChinaInstitute of Clinical Medical Sciences, China‐Japan Friendship Hospital Beijing ChinaAbstract Backgrounds We aimed to test whether the prediction of presurgical metabolic syndrome for postsurgical survival outcomes of gastric cancer hinges upon cigarette smoking status. Methods This study is a part of the ongoing Fujian prospective investigation of cancer (FIESTA) study. Patients with gastric cancer received radical resection of primary gastric cancer between January 2000 and December 2010, with the latest follow‐up ended in December 2015. The 1:1 propensity score matching analysis was adopted to balance confounders between smokers and never‐smokers. Effect‐size estimates are expressed as hazard ratio (HR) with 95% confidence interval (CI). Model performance was evaluated using the Hosmer and Lemeshow test and 10‐fold cross‐validated area under the receiver operating characteristic curve (AUROC). Statistical analyses were completed with SAS software (v9.4). Results Total 2779 patients with gastric cancer were analyzed, including 2223 smokers and 556 never‐smokers. Median follow‐up time was 45.6 months. Cigarette smoking was not associated with postsurgical survival differences. Presurgical metabolic syndrome complication was significantly associated with increased gastric cancer‐specific mortality in smokers (HR [95% CI]: 2.73 [1.53–4.89], p < 0.001), but not in never‐smokers. Relative excess risk due to interaction was estimated to be 2.43 (95% CI: 0.40–4.45). After constructing a risk assessment score, one unit increment was associated with 10% reduced risk of gastric cancer‐specific mortality (HR [95% CI]: 0.90 [0.88–0.91], p < 0.001), with 10‐fold cross‐validated AUROC being 0.82 (95% CI: 0.74–0.92). Conclusions Our findings showed that the prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality was more evident in smokers. Practically, this study provides evidence base for future personalized prediction and helped risk‐stratify gastric cancer patients who might experience serious postsurgical consequences.https://doi.org/10.1002/cam4.5116gastric cancermetabolic syndromepredictionrisk scoresmoking |
| spellingShingle | Xinran Zhang Dan Hu Xiangling Deng Jinxiu Lin Xiongwei Zheng Feng Peng Fanqiang Meng Wenquan Niu Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study Cancer Medicine gastric cancer metabolic syndrome prediction risk score smoking |
| title | Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study |
| title_full | Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study |
| title_fullStr | Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study |
| title_full_unstemmed | Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study |
| title_short | Prediction of presurgical metabolic syndrome for gastric cancer‐specific mortality is more evident in smokers: The FIESTA study |
| title_sort | prediction of presurgical metabolic syndrome for gastric cancer specific mortality is more evident in smokers the fiesta study |
| topic | gastric cancer metabolic syndrome prediction risk score smoking |
| url | https://doi.org/10.1002/cam4.5116 |
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