Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

Summary: Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation. Modulating the balance between functional p53 sel...

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Bibliographic Details
Main Authors: Antonio Galarreta, Virginia Pasti, Julia Vornberger, Ralph Imhof, Mariano Oppikofer, Matthias Altmeyer
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008617
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