Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics
[Objective] To investigate the positive rate of drug-induced antibodies produced by the clinical application of β-lactam antibiotics, and analyze the differences in the detection methods and related influencing factors. [Methods] A total of 350 adult inpatients who developed anemia after using β-lac...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-07-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.009&lang=en |
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| _version_ | 1850030023693565952 |
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| author | ZHENG Yangyang WANG Rongpeng ZHAO Jie ZHUO Bingzheng CHEN Feng |
| author_facet | ZHENG Yangyang WANG Rongpeng ZHAO Jie ZHUO Bingzheng CHEN Feng |
| author_sort | ZHENG Yangyang |
| collection | DOAJ |
| description | [Objective] To investigate the positive rate of drug-induced antibodies produced by the clinical application of β-lactam antibiotics, and analyze the differences in the detection methods and related influencing factors. [Methods] A total of 350 adult inpatients who developed anemia after using β-lactam antibiotics for 3 days or more in Inner Mongolia People's hospital were selected as the experimental group, and 240 adult inpatients treated with β-lactam antibiotics for 3 days or more who did not develop anemia as the control group. The drug-induced antibody tests, direct antiglobulin tests, and unexpected antibody screening were performed on both groups, and the influencing factors of drug-induced antibodies were analyzed. [Results] The numbers of positive cases of drug-induced antibody detected by the drug-coated red blood cell method in the experimental group and the control group were 12(12/350, 3.43%) and 2(2/240, 0.83%) respectively, with statistically significant differences (P<0.05). No drug-induced antibodies were detected in either group using the drug addition method. In the experimental group, the red blood cell method detected β-lactam drug-induced antibodies in 12 cases (12/350, 3.43%), while the drug added method detected 0 cases (0/350, 0.00%), with statistically significant differences (P<0.05). In the control group, the detection rates of two methods showed no statistically significant difference (P>0.05). In the experimental group, 7 cases of β-lactam antibodies were detected in the cephalosporin group (7/293, 2.40%) and 5 cases in the non-cephalosporin group (5/58, 8.62%), with statistically significant differences (P<0.05). There was no statistically significant difference between the second-generation and third-generation cephalosporin drugs (P>0.05). When the experimental group was stratified according to the history of blood transfusion and the blood type of patients, no statistically significant differences were observed between subgroups (P>0.05). [Conclusion] Anemia may be related to the production of drug-induced antibodies followingβ-lactam antibiotics treatment. Therefore, improving the clinical awareness of drug-induced antibodies to β-lactam antibiotics is of great significance to clarify the causes of anemia and reduce unnecessary blood transfusions. |
| format | Article |
| id | doaj-art-890774fb2ac54aa08e1409d759745fc6 |
| institution | DOAJ |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-890774fb2ac54aa08e1409d759745fc62025-08-20T02:59:19ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-07-0138792292710.13303/j.cjbt.issn.1004-549x.2025.07.0091004-549X(2025)7-0922-06Detection and clinical analysis of drug-induced antibodies related to β-lactam antibioticsZHENG Yangyang0WANG Rongpeng1ZHAO Jie2ZHUO Bingzheng3CHEN Feng4Department of Clinical Transfusion, Inner Mongolia People's Hospital, Hohhot 010017, ChinaDepartment of Transfusion, Tongliao People's Hospital, Tongliao 028000, ChinaDepartment of Laboratory Medicine, Taiyuan Central Hospital, Taiyuan 030000, ChinaDepartment of Clinical Transfusion, Inner Mongolia People's Hospital, Hohhot 010017, ChinaDepartment of Clinical Transfusion, Inner Mongolia People's Hospital, Hohhot 010017, China[Objective] To investigate the positive rate of drug-induced antibodies produced by the clinical application of β-lactam antibiotics, and analyze the differences in the detection methods and related influencing factors. [Methods] A total of 350 adult inpatients who developed anemia after using β-lactam antibiotics for 3 days or more in Inner Mongolia People's hospital were selected as the experimental group, and 240 adult inpatients treated with β-lactam antibiotics for 3 days or more who did not develop anemia as the control group. The drug-induced antibody tests, direct antiglobulin tests, and unexpected antibody screening were performed on both groups, and the influencing factors of drug-induced antibodies were analyzed. [Results] The numbers of positive cases of drug-induced antibody detected by the drug-coated red blood cell method in the experimental group and the control group were 12(12/350, 3.43%) and 2(2/240, 0.83%) respectively, with statistically significant differences (P<0.05). No drug-induced antibodies were detected in either group using the drug addition method. In the experimental group, the red blood cell method detected β-lactam drug-induced antibodies in 12 cases (12/350, 3.43%), while the drug added method detected 0 cases (0/350, 0.00%), with statistically significant differences (P<0.05). In the control group, the detection rates of two methods showed no statistically significant difference (P>0.05). In the experimental group, 7 cases of β-lactam antibodies were detected in the cephalosporin group (7/293, 2.40%) and 5 cases in the non-cephalosporin group (5/58, 8.62%), with statistically significant differences (P<0.05). There was no statistically significant difference between the second-generation and third-generation cephalosporin drugs (P>0.05). When the experimental group was stratified according to the history of blood transfusion and the blood type of patients, no statistically significant differences were observed between subgroups (P>0.05). [Conclusion] Anemia may be related to the production of drug-induced antibodies followingβ-lactam antibiotics treatment. Therefore, improving the clinical awareness of drug-induced antibodies to β-lactam antibiotics is of great significance to clarify the causes of anemia and reduce unnecessary blood transfusions.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.009&lang=endrug-induced antibodiesβ-lactam antibioticsanemiadrug-induced immunohemolytic anemia |
| spellingShingle | ZHENG Yangyang WANG Rongpeng ZHAO Jie ZHUO Bingzheng CHEN Feng Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics Zhongguo shuxue zazhi drug-induced antibodies β-lactam antibiotics anemia drug-induced immunohemolytic anemia |
| title | Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics |
| title_full | Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics |
| title_fullStr | Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics |
| title_full_unstemmed | Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics |
| title_short | Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics |
| title_sort | detection and clinical analysis of drug induced antibodies related to β lactam antibiotics |
| topic | drug-induced antibodies β-lactam antibiotics anemia drug-induced immunohemolytic anemia |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.009&lang=en |
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