Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor
Two separate episodes of transfusion-related acute lung injury (TRALI) in thalassaemia patients caused by red blood cell transfusions from the same multiparous blood donor are reported. Both cases had the same symptomatology and occurred 10-60 minutes of transfusion. The patients presented dyspnea,...
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PAGEPress Publications
2017-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/3078 |
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| author | George J Kontoghiorghes |
| author_facet | George J Kontoghiorghes |
| author_sort | George J Kontoghiorghes |
| collection | DOAJ |
| description | Two separate episodes of transfusion-related acute lung injury (TRALI) in thalassaemia patients caused by red blood cell transfusions from the same multiparous blood donor are reported. Both cases had the same symptomatology and occurred 10-60 minutes of transfusion. The patients presented dyspnea, sweating, fatigue, dizziness, fever, and sense of losing consciousness. The chest x-ray showed a pulmonary oedema-like picture with both lungs filled with fluid. The patients were treated in the intensive therapy unit. They were weaned off the ventilator and discharged following hospitalization 7 and 9 days respectively. The TRALI syndrome was diagnosed to be associated with HLA-specific donor antibodies against mismatched HLA-antigens of the transfused patients. Haemovigilance improvements are essential for reducing the morbidity and mortality in transfused patients. Blood from multiparous donors should be tested for the presence of IgG HLA-Class I and –Class II antibodies before being transfused in thalassaemia and other chronically transfused patients. |
| format | Article |
| id | doaj-art-8905dc7e1601440e8a37c1bec8152edb |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-8905dc7e1601440e8a37c1bec8152edb2025-08-20T01:47:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062017-10-0191e2017060e201706010.4084/mjhid.2017.0601715Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donorGeorge J Kontoghiorghes0Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, CyprusTwo separate episodes of transfusion-related acute lung injury (TRALI) in thalassaemia patients caused by red blood cell transfusions from the same multiparous blood donor are reported. Both cases had the same symptomatology and occurred 10-60 minutes of transfusion. The patients presented dyspnea, sweating, fatigue, dizziness, fever, and sense of losing consciousness. The chest x-ray showed a pulmonary oedema-like picture with both lungs filled with fluid. The patients were treated in the intensive therapy unit. They were weaned off the ventilator and discharged following hospitalization 7 and 9 days respectively. The TRALI syndrome was diagnosed to be associated with HLA-specific donor antibodies against mismatched HLA-antigens of the transfused patients. Haemovigilance improvements are essential for reducing the morbidity and mortality in transfused patients. Blood from multiparous donors should be tested for the presence of IgG HLA-Class I and –Class II antibodies before being transfused in thalassaemia and other chronically transfused patients.http://www.mjhid.org/index.php/mjhid/article/view/3078Thalassemic SyndromesAnemiaTRALI |
| spellingShingle | George J Kontoghiorghes Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor Mediterranean Journal of Hematology and Infectious Diseases Thalassemic Syndromes Anemia TRALI |
| title | Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor |
| title_full | Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor |
| title_fullStr | Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor |
| title_full_unstemmed | Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor |
| title_short | Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor |
| title_sort | transfusion related acute lung injury trali in two thalassaemia patients caused by the same multiparous blood donor |
| topic | Thalassemic Syndromes Anemia TRALI |
| url | http://www.mjhid.org/index.php/mjhid/article/view/3078 |
| work_keys_str_mv | AT georgejkontoghiorghes transfusionrelatedacutelunginjurytraliintwothalassaemiapatientscausedbythesamemultiparousblooddonor |