Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine

Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine

IntroductionThe rapid development and deployment of multiple safe and effective COVID-19 vaccines were critical cornerstones of pandemic control. However, vaccine inequity and the emergence of new variants of concern (VOCs) highlighted major gaps in the global strategy to control SARS-CoV-2 infectio...

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Main Authors: João Pedro da Silva Nunes, Mariângela de Oliveira Silva, Juliana de Souza Apostolico, Isabela Pazotti Daher, Rodolfo Ferreira Marques, Marcio Massao Yamamoto, Alexia Adrianne Venceslau Brito Carvalho, Maria Fernanda de Castro-Amarante, Edison Luiz Durigon, Carsten Wrenger, Luiz Mario Ramos Janini, Edmarcia Elisa de Souza, Robert Andreata-Santos, Juliana Terzi Maricato, Edecio Cunha-Neto, Jorge Kalil, Silvia Beatriz Boscardin, Daniela Santoro Rosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
RBD
vaccine
recombinant protein
adjuvant
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610422/full
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