Wegener's granulomatosis in a 15-year-old boy
Wegener's granulomatosis (WG) is an uncommon systemic vasculitis that is rarely encountered in children. A 15-year old boy presented with a one-month history of nasal obstruction, hemorrhagic rhinorrhea, malaise, fever, anorexia and weight loss, together with high values of inflammatory...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2003-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2923 |
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| author | Sylva Skálová Lenka Minxová Miroslav Podhola |
| author_facet | Sylva Skálová Lenka Minxová Miroslav Podhola |
| author_sort | Sylva Skálová |
| collection | DOAJ |
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Wegener's granulomatosis (WG) is an uncommon systemic vasculitis that is rarely encountered in children. A 15-year old boy presented with a one-month history of nasal obstruction, hemorrhagic rhinorrhea, malaise, fever, anorexia and weight loss, together with high values of inflammatory markers, microscopic hematuria and progressive decrease of renal functions. Renal biopsy revealed rapidly progressive crescentic glomerulonephritis with rare findings of interstitial and periglomerular granulomas. The diagnosis of WG was established and intravenous methylprednisolone and cyclophosphamide therapy followed by oral application of prednisone and azathioprine led to a complete clinical and laboratory remission of the disease. The second renal biopsy performed after 28 months of treatment did not show any activity of the process. Currently, the boy is without any clinical or laboratory signs of active disease. Since untreated WG has a fatal prognosis, early diagnosis and appropriately aggressive immunosuppressive therapy are necessary for a favorable outcome.
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| format | Article |
| id | doaj-art-8903e0d3bda1448a8f1fa14c2c5e34d2 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2003-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8903e0d3bda1448a8f1fa14c2c5e34d22025-08-20T03:00:55ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212003-10-01454Wegener's granulomatosis in a 15-year-old boySylva Skálová0Lenka MinxováMiroslav PodholaDepartment of Pediatrics, Medical Faculty, Teaching Hospital, Charles University, Hradec Králové, Czech Republic. Wegener's granulomatosis (WG) is an uncommon systemic vasculitis that is rarely encountered in children. A 15-year old boy presented with a one-month history of nasal obstruction, hemorrhagic rhinorrhea, malaise, fever, anorexia and weight loss, together with high values of inflammatory markers, microscopic hematuria and progressive decrease of renal functions. Renal biopsy revealed rapidly progressive crescentic glomerulonephritis with rare findings of interstitial and periglomerular granulomas. The diagnosis of WG was established and intravenous methylprednisolone and cyclophosphamide therapy followed by oral application of prednisone and azathioprine led to a complete clinical and laboratory remission of the disease. The second renal biopsy performed after 28 months of treatment did not show any activity of the process. Currently, the boy is without any clinical or laboratory signs of active disease. Since untreated WG has a fatal prognosis, early diagnosis and appropriately aggressive immunosuppressive therapy are necessary for a favorable outcome. https://turkjpediatr.org/article/view/2923 |
| spellingShingle | Sylva Skálová Lenka Minxová Miroslav Podhola Wegener's granulomatosis in a 15-year-old boy The Turkish Journal of Pediatrics |
| title | Wegener's granulomatosis in a 15-year-old boy |
| title_full | Wegener's granulomatosis in a 15-year-old boy |
| title_fullStr | Wegener's granulomatosis in a 15-year-old boy |
| title_full_unstemmed | Wegener's granulomatosis in a 15-year-old boy |
| title_short | Wegener's granulomatosis in a 15-year-old boy |
| title_sort | wegener s granulomatosis in a 15 year old boy |
| url | https://turkjpediatr.org/article/view/2923 |
| work_keys_str_mv | AT sylvaskalova wegenersgranulomatosisina15yearoldboy AT lenkaminxova wegenersgranulomatosisina15yearoldboy AT miroslavpodhola wegenersgranulomatosisina15yearoldboy |