Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report
Ectopic adrenocorticotropic hormone production is an extremely rare cause of Cushing syndrome in pregnancy and is associated with significant morbidity. A 37-year-old multiparous woman at 32 weeks’ gestation presented with hypertension, anasarca, hypokalemia, and fetal distress requiring an urgent c...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-07-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2021.0238 |
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| author | Wei-She Julia Tai Richa Parihar Mary Ellene Boulos Hertzel Gerstein Meera Luthra Ahraaz Wyne |
| author_facet | Wei-She Julia Tai Richa Parihar Mary Ellene Boulos Hertzel Gerstein Meera Luthra Ahraaz Wyne |
| author_sort | Wei-She Julia Tai |
| collection | DOAJ |
| description | Ectopic adrenocorticotropic hormone production is an extremely rare cause of Cushing syndrome in pregnancy and is associated with significant morbidity. A 37-year-old multiparous woman at 32 weeks’ gestation presented with hypertension, anasarca, hypokalemia, and fetal distress requiring an urgent cesarean section. Her adrenocorticotropic hormone and cortisol levels were elevated, and high-dose dexamethasone failed to suppress them, suggesting ectopic adrenocorticotropic hormone production. Multimodality imaging did not identify a source, and she had urgent bilateral adrenalectomy for refractory severe hypercortisolism. Ectopic Cushing syndrome in pregnancy requires a high index of suspicion for diagnostic testing and prompt treatment to minimize maternal and fetal complications. |
| format | Article |
| id | doaj-art-88ff07b9281e4f35a0b221a3bce8d0cb |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-88ff07b9281e4f35a0b221a3bce8d0cb2025-08-20T03:18:49ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-07-011510.7326/aimcc.2021.0238Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case ReportWei-She Julia Tai0Richa Parihar1Mary Ellene Boulos2Hertzel Gerstein3Meera Luthra4Ahraaz Wyne51University of Ottawa, Ottawa, Ontario, Canada2McMaster University, Hamilton, Ontario, Canada2McMaster University, Hamilton, Ontario, Canada2McMaster University, Hamilton, Ontario, Canada2McMaster University, Hamilton, Ontario, Canada2McMaster University, Hamilton, Ontario, CanadaEctopic adrenocorticotropic hormone production is an extremely rare cause of Cushing syndrome in pregnancy and is associated with significant morbidity. A 37-year-old multiparous woman at 32 weeks’ gestation presented with hypertension, anasarca, hypokalemia, and fetal distress requiring an urgent cesarean section. Her adrenocorticotropic hormone and cortisol levels were elevated, and high-dose dexamethasone failed to suppress them, suggesting ectopic adrenocorticotropic hormone production. Multimodality imaging did not identify a source, and she had urgent bilateral adrenalectomy for refractory severe hypercortisolism. Ectopic Cushing syndrome in pregnancy requires a high index of suspicion for diagnostic testing and prompt treatment to minimize maternal and fetal complications.https://www.acpjournals.org/doi/10.7326/aimcc.2021.0238 |
| spellingShingle | Wei-She Julia Tai Richa Parihar Mary Ellene Boulos Hertzel Gerstein Meera Luthra Ahraaz Wyne Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report |
| title_full | Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report |
| title_fullStr | Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report |
| title_full_unstemmed | Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report |
| title_short | Cushing Syndrome Secondary to Ectopic ACTH Production in Pregnancy: A Case Report |
| title_sort | cushing syndrome secondary to ectopic acth production in pregnancy a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2021.0238 |
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