The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico
Background: Depression is one of the most prevalent mental health disorders worldwide, affecting a significant proportion of the global population. Its etiology is complex and influenced by the interaction of environmental factors and genetic variations. In Mexico, it has been reported that 41.3% of...
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2025-05-01
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| author | Margarita Hernandez-Mixteco Olga Lidia Valenzuela Cecilia Luz Balderas-Vazquez Paola Castillo-Juárez Sandra Rivera-Gutiérrez Rocío Liliana García-Reyes Gilberto Cornejo-Estudillo Ricardo Jiovanni Soria-Herrera Moises León-Juárez Addy Cecilia Helguera-Repetto Daniel Valencia-Trujillo Victoria Campos-Peña Eliud Alfredo Garcia-Montalvo Jorge Francisco Cerna-Cortés |
| author_facet | Margarita Hernandez-Mixteco Olga Lidia Valenzuela Cecilia Luz Balderas-Vazquez Paola Castillo-Juárez Sandra Rivera-Gutiérrez Rocío Liliana García-Reyes Gilberto Cornejo-Estudillo Ricardo Jiovanni Soria-Herrera Moises León-Juárez Addy Cecilia Helguera-Repetto Daniel Valencia-Trujillo Victoria Campos-Peña Eliud Alfredo Garcia-Montalvo Jorge Francisco Cerna-Cortés |
| author_sort | Margarita Hernandez-Mixteco |
| collection | DOAJ |
| description | Background: Depression is one of the most prevalent mental health disorders worldwide, affecting a significant proportion of the global population. Its etiology is complex and influenced by the interaction of environmental factors and genetic variations. In Mexico, it has been reported that 41.3% of the population exhibits depressive symptoms. Previous studies have suggested that susceptibility to depression may be associated with the C-1019G (rs6295) polymorphism in the serotonin 1A (5-HT1A) receptor gene. Objective: In this study, we aimed to evaluate the association between the C-1019G polymorphism and depressive symptoms in a rural Mexican population. Methods: Using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP), we examined the effect of C-1019G on depression symptoms, as evaluated by the Beck Depression Inventory. Data were obtained from 83 volunteers; individuals with depressive symptoms and those with a healthy mood were compared. Results: The results showed that the homozygous C/C genotype was found significantly more frequently in the control group than in individuals with depressive symptoms, particularly among men, and is thus associated with a decreased risk of depressive symptomatology. Conclusions: The C/C genotype could protect against susceptibility to developing depressive symptoms in a rural population in Mexico. |
| format | Article |
| id | doaj-art-88fed0bf0c5747d482bcea6bfdb3ed37 |
| institution | Kabale University |
| issn | 2035-8377 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-88fed0bf0c5747d482bcea6bfdb3ed372025-08-20T03:29:45ZengMDPI AGNeurology International2035-83772025-05-011768710.3390/neurolint17060087The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in MexicoMargarita Hernandez-Mixteco0Olga Lidia Valenzuela1Cecilia Luz Balderas-Vazquez2Paola Castillo-Juárez3Sandra Rivera-Gutiérrez4Rocío Liliana García-Reyes5Gilberto Cornejo-Estudillo6Ricardo Jiovanni Soria-Herrera7Moises León-Juárez8Addy Cecilia Helguera-Repetto9Daniel Valencia-Trujillo10Victoria Campos-Peña11Eliud Alfredo Garcia-Montalvo12Jorge Francisco Cerna-Cortés13Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz 94340, MexicoCoordinación de Ingeniería Biomédica, Universidad Anáhuac, Campus Córdoba, Veracruz 94500, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoEscuela José Ma. Pastrana. Secretaría de Educación Pública, Yecapixtla, Morelos 62829, MexicoFacultad de Químico Farmacobiología, Universidad Michoacana de San Nicolas de Hidalgo, Morelia Michoacán 58240, MexicoDepartamento de Inmunobioquimica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México 11000, MexicoDepartamento de Inmunobioquimica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México 11000, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoLaboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Ciudad de México 14269, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz 94340, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoBackground: Depression is one of the most prevalent mental health disorders worldwide, affecting a significant proportion of the global population. Its etiology is complex and influenced by the interaction of environmental factors and genetic variations. In Mexico, it has been reported that 41.3% of the population exhibits depressive symptoms. Previous studies have suggested that susceptibility to depression may be associated with the C-1019G (rs6295) polymorphism in the serotonin 1A (5-HT1A) receptor gene. Objective: In this study, we aimed to evaluate the association between the C-1019G polymorphism and depressive symptoms in a rural Mexican population. Methods: Using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP), we examined the effect of C-1019G on depression symptoms, as evaluated by the Beck Depression Inventory. Data were obtained from 83 volunteers; individuals with depressive symptoms and those with a healthy mood were compared. Results: The results showed that the homozygous C/C genotype was found significantly more frequently in the control group than in individuals with depressive symptoms, particularly among men, and is thus associated with a decreased risk of depressive symptomatology. Conclusions: The C/C genotype could protect against susceptibility to developing depressive symptoms in a rural population in Mexico.https://www.mdpi.com/2035-8377/17/6/87depression symptoms5-HT1A receptor geneC-1019G polymorphismMexican population |
| spellingShingle | Margarita Hernandez-Mixteco Olga Lidia Valenzuela Cecilia Luz Balderas-Vazquez Paola Castillo-Juárez Sandra Rivera-Gutiérrez Rocío Liliana García-Reyes Gilberto Cornejo-Estudillo Ricardo Jiovanni Soria-Herrera Moises León-Juárez Addy Cecilia Helguera-Repetto Daniel Valencia-Trujillo Victoria Campos-Peña Eliud Alfredo Garcia-Montalvo Jorge Francisco Cerna-Cortés The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico Neurology International depression symptoms 5-HT1A receptor gene C-1019G polymorphism Mexican population |
| title | The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico |
| title_full | The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico |
| title_fullStr | The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico |
| title_full_unstemmed | The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico |
| title_short | The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico |
| title_sort | c c genotype of the c 1019g rs6295 polymorphism of the 5 ht1a receptor gene is associated with lower susceptibility to depressive symptoms in a rural population in mexico |
| topic | depression symptoms 5-HT1A receptor gene C-1019G polymorphism Mexican population |
| url | https://www.mdpi.com/2035-8377/17/6/87 |
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