Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma
Relevance. Bronchial asthma is widespread in the world, according to WHO estimates, 235 million people suffer from it. In Russia, according to official figures, 1.3 million cases of bronchial asthma have been reported. Domestic experts reasonably believe that these data are underestimated at least 4...
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Numikom LLC
2019-09-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/795 |
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| author | N. P. Andreeva A. V. Protasov T. A. Kostinovа S. V. Lezhenina |
| author_facet | N. P. Andreeva A. V. Protasov T. A. Kostinovа S. V. Lezhenina |
| author_sort | N. P. Andreeva |
| collection | DOAJ |
| description | Relevance. Bronchial asthma is widespread in the world, according to WHO estimates, 235 million people suffer from it. In Russia, according to official figures, 1.3 million cases of bronchial asthma have been reported. Domestic experts reasonably believe that these data are underestimated at least 4 times. Considering that patients with bronchial asthma undergo significant changes in the immune system and are especially difficult to tolerate respiratory and other infectious diseases, determining the effect of vaccination on the clinical course of bronchial asthma is very important. The purpose of the review is to show how vaccinations against pneumococcal infection and influenza affect the condition of patients with bronchial asthma. Conclusion. Features of formation of protective immunity at various schemes of immunization against pneumococcal infection are analyzed. In patients with bronchial asthma, the justification of the vaccination scheme with the advantage of the priority administration of conjugated polysaccharide vaccine with the subsequent introduction of a polysaccharide pneumococcal vaccine after 8 weeks is given. Vaccination against pneumococcal infections has led to the elimination of sputum S. рneumoniae. In vaccination against pneumococcal infection, there was an improvement in the level of disease control, which was confirmed by the ACQ-5 test-a decrease in the indicator from 2 [1,5;1,8;3] points (lack of asthma control) to 0,6 [0;1] points (asthma control) during the year of observation, p < 0,001. Vaccination against influenza in patients with bronchial asthma leads to a decrease in the frequency and duration of exacerbations, there is a decrease in the level of markers of systemic inflammation. Combined vaccination against influenza and pneumococcal infection is not accompanied by a reliable difference in tolerability in comparison with monovaccination only against pneumococcal infection or influenza. |
| format | Article |
| id | doaj-art-88f6306d1dc1468b94d0770c1e137550 |
| institution | Kabale University |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-88f6306d1dc1468b94d0770c1e1375502025-08-20T03:43:46ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942019-09-011849310010.31631/2073-3046-2019-18-4-93-100557Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial AsthmaN. P. Andreeva0A. V. Protasov1T. A. Kostinovа2S. V. Lezhenina3Chuvash State University named after I. N. Ulyanov; City children's clinical hospitalSamara State Medical UniversityMoscow research and practical center for tuberculosis control of Moscow Department of healthChuvash State University named after I. N. UlyanovRelevance. Bronchial asthma is widespread in the world, according to WHO estimates, 235 million people suffer from it. In Russia, according to official figures, 1.3 million cases of bronchial asthma have been reported. Domestic experts reasonably believe that these data are underestimated at least 4 times. Considering that patients with bronchial asthma undergo significant changes in the immune system and are especially difficult to tolerate respiratory and other infectious diseases, determining the effect of vaccination on the clinical course of bronchial asthma is very important. The purpose of the review is to show how vaccinations against pneumococcal infection and influenza affect the condition of patients with bronchial asthma. Conclusion. Features of formation of protective immunity at various schemes of immunization against pneumococcal infection are analyzed. In patients with bronchial asthma, the justification of the vaccination scheme with the advantage of the priority administration of conjugated polysaccharide vaccine with the subsequent introduction of a polysaccharide pneumococcal vaccine after 8 weeks is given. Vaccination against pneumococcal infections has led to the elimination of sputum S. рneumoniae. In vaccination against pneumococcal infection, there was an improvement in the level of disease control, which was confirmed by the ACQ-5 test-a decrease in the indicator from 2 [1,5;1,8;3] points (lack of asthma control) to 0,6 [0;1] points (asthma control) during the year of observation, p < 0,001. Vaccination against influenza in patients with bronchial asthma leads to a decrease in the frequency and duration of exacerbations, there is a decrease in the level of markers of systemic inflammation. Combined vaccination against influenza and pneumococcal infection is not accompanied by a reliable difference in tolerability in comparison with monovaccination only against pneumococcal infection or influenza.https://www.epidemvac.ru/jour/article/view/795pneumococcal infectionvaccinationasthmafluvaccination scheme |
| spellingShingle | N. P. Andreeva A. V. Protasov T. A. Kostinovа S. V. Lezhenina Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma Эпидемиология и вакцинопрофилактика pneumococcal infection vaccination asthma flu vaccination scheme |
| title | Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma |
| title_full | Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma |
| title_fullStr | Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma |
| title_full_unstemmed | Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma |
| title_short | Effect of Vaccination against Pneumococcal Infection and Influenza on the Clinical Course of Bronchial Asthma |
| title_sort | effect of vaccination against pneumococcal infection and influenza on the clinical course of bronchial asthma |
| topic | pneumococcal infection vaccination asthma flu vaccination scheme |
| url | https://www.epidemvac.ru/jour/article/view/795 |
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