Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, and challenges i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/1/136 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587721741172736 |
|---|---|
| author | Shery Jacob Fathima Sheik Kather Sai H. S. Boddu Mahesh Attimarad Anroop B. Nair |
| author_facet | Shery Jacob Fathima Sheik Kather Sai H. S. Boddu Mahesh Attimarad Anroop B. Nair |
| author_sort | Shery Jacob |
| collection | DOAJ |
| description | Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, and challenges in NS-based drug delivery, particularly for oral, ocular, transdermal, pulmonary, and parenteral routes. The conversion of oral NS into powders, pellets, granules, tablets, and capsules, and their incorporation into film dosage forms to address stability concerns is thoroughly reviewed. This article summarizes key stabilizers, polymers, surfactants, and excipients used in NS formulations, along with ongoing clinical trials and recent patents. Furthermore, a comprehensive analysis of various methods for NS preparation is provided. This article also explores various in vitro and in vivo characterization techniques, as well as scale-down technologies and bottom-up methods for NS preparation. Selected examples of commercial NS drug products are discussed. Rapid advances in the field of NS could resolve issues related to permeability-limited absorption and hepatic first-pass metabolism, offering promise for medications based on proteins and peptides. The evolution of novel stabilizers is essential to overcome the current limitations in NS formulations, enhancing their stability, bioavailability, targeting ability, and safety profile, which ultimately accelerates their clinical application and commercialization. |
| format | Article |
| id | doaj-art-88f46eb0d53849f8afd15d17b1dc5f22 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-88f46eb0d53849f8afd15d17b1dc5f222025-01-24T13:46:06ZengMDPI AGPharmaceutics1999-49232025-01-0117113610.3390/pharmaceutics17010136Nanosuspension Innovations: Expanding Horizons in Drug Delivery TechniquesShery Jacob0Fathima Sheik Kather1Sai H. S. Boddu2Mahesh Attimarad3Anroop B. Nair4Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman P.O. Box 346, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaNanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, and challenges in NS-based drug delivery, particularly for oral, ocular, transdermal, pulmonary, and parenteral routes. The conversion of oral NS into powders, pellets, granules, tablets, and capsules, and their incorporation into film dosage forms to address stability concerns is thoroughly reviewed. This article summarizes key stabilizers, polymers, surfactants, and excipients used in NS formulations, along with ongoing clinical trials and recent patents. Furthermore, a comprehensive analysis of various methods for NS preparation is provided. This article also explores various in vitro and in vivo characterization techniques, as well as scale-down technologies and bottom-up methods for NS preparation. Selected examples of commercial NS drug products are discussed. Rapid advances in the field of NS could resolve issues related to permeability-limited absorption and hepatic first-pass metabolism, offering promise for medications based on proteins and peptides. The evolution of novel stabilizers is essential to overcome the current limitations in NS formulations, enhancing their stability, bioavailability, targeting ability, and safety profile, which ultimately accelerates their clinical application and commercialization.https://www.mdpi.com/1999-4923/17/1/136nanosuspensionnanocrystalsolid dispersionpreparation methodsstabilizersdrug delivery systems |
| spellingShingle | Shery Jacob Fathima Sheik Kather Sai H. S. Boddu Mahesh Attimarad Anroop B. Nair Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques Pharmaceutics nanosuspension nanocrystal solid dispersion preparation methods stabilizers drug delivery systems |
| title | Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques |
| title_full | Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques |
| title_fullStr | Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques |
| title_full_unstemmed | Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques |
| title_short | Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques |
| title_sort | nanosuspension innovations expanding horizons in drug delivery techniques |
| topic | nanosuspension nanocrystal solid dispersion preparation methods stabilizers drug delivery systems |
| url | https://www.mdpi.com/1999-4923/17/1/136 |
| work_keys_str_mv | AT sheryjacob nanosuspensioninnovationsexpandinghorizonsindrugdeliverytechniques AT fathimasheikkather nanosuspensioninnovationsexpandinghorizonsindrugdeliverytechniques AT saihsboddu nanosuspensioninnovationsexpandinghorizonsindrugdeliverytechniques AT maheshattimarad nanosuspensioninnovationsexpandinghorizonsindrugdeliverytechniques AT anroopbnair nanosuspensioninnovationsexpandinghorizonsindrugdeliverytechniques |