The study of consistent properties of the vasopressin nasal dosage form
Evaluation of consistent properties is an important and integral part of investigations on the creation of semisolid nasal pharmacotherapeutic agents. The aim of this work is the study of consistent properties of developed nasal semisolid dosage form with synthetic analogue of vasopressin – argin...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2016-12-01
|
| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| Subjects: | |
| Online Access: | http://pharmed.zsmu.edu.ua/article/view/77932/75940 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850054937822625792 |
|---|---|
| author | Al Nukarii Abdulkarim A. L. Drozdov A. P. Lysyanskaya |
| author_facet | Al Nukarii Abdulkarim A. L. Drozdov A. P. Lysyanskaya |
| author_sort | Al Nukarii Abdulkarim |
| collection | DOAJ |
| description | Evaluation of consistent properties is an important and integral part of investigations on the creation of semisolid nasal pharmacotherapeutic agents.
The aim of this work is the study of consistent properties of developed nasal semisolid dosage form with synthetic analogue of vasopressin – arginine-vasopressin for the treatment of cognitive consequences of cerebral-vascular pathology.
Materials and methods. The study of structural-mechanical characteristics of nasal ointment with 0.000005% arginine-vasopressin on the vaseline-lanolin-paraffin base was carried out by a rotary viscosimeter «Reotest-2» with cylindrical arrangement. It was established that consistent properties of arginine-vasopressin semisolid dosage form and «mechanical stability» (2.56) describe composition as a thixotropic system which provides with restorability after applying tension and allow to predict stability of consistent properties during a long-term storage. Calculated factors of dynamical flowing of arginine- vasopressin dosage form on the vaseline-lanolin-paraffin base (Кd1=28.7%; Kd2=53.84%) quantitatively confirm satisfactory spreading degree of the system during application on the mucous membranes or in manufacturing process.
Conclusions. The studies of consistent properties of nasal ointment with synthetic analogue of vasopressin – arginine-vasopressin 0.000005% on lipophilic basis for treatment of cognitive effects of cerebrovascular disease have been conducted by rotary viscometer «Reotest 2».
It has been established that consistent properties of studied soft nasal dosage form of arginine-vasopressin and «mechanical stability» value of the system (2.56) characterize it as a thixotropic, that assure recovery from mechanical stress, that allows to predict the stability of consistent properties of the composition during prolonged storage.
The calculated values of coefficients of dynamic flow of intranasal dosage form of arginine-vasopressin on vaseline-lanolin-paraffin base (Кd1=28.7%; Kd2=53.84%) quantitatively confirm satisfactory level of system distribution during application on mucous membranes or at manufacturing process operations. |
| format | Article |
| id | doaj-art-88f23ce277ba410087a5f74e39b46410 |
| institution | DOAJ |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-88f23ce277ba410087a5f74e39b464102025-08-20T02:52:06ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322016-12-013374010.14739/2409-2932.2016.3.77932The study of consistent properties of the vasopressin nasal dosage formAl Nukarii AbdulkarimA. L. Drozdov A. P. LysyanskayaEvaluation of consistent properties is an important and integral part of investigations on the creation of semisolid nasal pharmacotherapeutic agents. The aim of this work is the study of consistent properties of developed nasal semisolid dosage form with synthetic analogue of vasopressin – arginine-vasopressin for the treatment of cognitive consequences of cerebral-vascular pathology. Materials and methods. The study of structural-mechanical characteristics of nasal ointment with 0.000005% arginine-vasopressin on the vaseline-lanolin-paraffin base was carried out by a rotary viscosimeter «Reotest-2» with cylindrical arrangement. It was established that consistent properties of arginine-vasopressin semisolid dosage form and «mechanical stability» (2.56) describe composition as a thixotropic system which provides with restorability after applying tension and allow to predict stability of consistent properties during a long-term storage. Calculated factors of dynamical flowing of arginine- vasopressin dosage form on the vaseline-lanolin-paraffin base (Кd1=28.7%; Kd2=53.84%) quantitatively confirm satisfactory spreading degree of the system during application on the mucous membranes or in manufacturing process. Conclusions. The studies of consistent properties of nasal ointment with synthetic analogue of vasopressin – arginine-vasopressin 0.000005% on lipophilic basis for treatment of cognitive effects of cerebrovascular disease have been conducted by rotary viscometer «Reotest 2». It has been established that consistent properties of studied soft nasal dosage form of arginine-vasopressin and «mechanical stability» value of the system (2.56) characterize it as a thixotropic, that assure recovery from mechanical stress, that allows to predict the stability of consistent properties of the composition during prolonged storage. The calculated values of coefficients of dynamic flow of intranasal dosage form of arginine-vasopressin on vaseline-lanolin-paraffin base (Кd1=28.7%; Kd2=53.84%) quantitatively confirm satisfactory level of system distribution during application on mucous membranes or at manufacturing process operations.http://pharmed.zsmu.edu.ua/article/view/77932/75940Arginine VasopressinOintmentsThixotropy |
| spellingShingle | Al Nukarii Abdulkarim A. L. Drozdov A. P. Lysyanskaya The study of consistent properties of the vasopressin nasal dosage form Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Arginine Vasopressin Ointments Thixotropy |
| title | The study of consistent properties of the vasopressin nasal dosage form |
| title_full | The study of consistent properties of the vasopressin nasal dosage form |
| title_fullStr | The study of consistent properties of the vasopressin nasal dosage form |
| title_full_unstemmed | The study of consistent properties of the vasopressin nasal dosage form |
| title_short | The study of consistent properties of the vasopressin nasal dosage form |
| title_sort | study of consistent properties of the vasopressin nasal dosage form |
| topic | Arginine Vasopressin Ointments Thixotropy |
| url | http://pharmed.zsmu.edu.ua/article/view/77932/75940 |
| work_keys_str_mv | AT alnukariiabdulkarim thestudyofconsistentpropertiesofthevasopressinnasaldosageform AT aldrozdov thestudyofconsistentpropertiesofthevasopressinnasaldosageform AT aplysyanskaya thestudyofconsistentpropertiesofthevasopressinnasaldosageform AT alnukariiabdulkarim studyofconsistentpropertiesofthevasopressinnasaldosageform AT aldrozdov studyofconsistentpropertiesofthevasopressinnasaldosageform AT aplysyanskaya studyofconsistentpropertiesofthevasopressinnasaldosageform |