Pharmacological Treatment Of Osteoarthritis In A Nutshell
Osteoarthritis, an inflammatory, degenerative disease of joints mostly affects weight bearing joints in old age. Treatment modalities are categorized into non-pharmacological, pharmacological and surgical. Among pharmacological options, oral formulations are mostly used. Acetaminophen is considered...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2019-03-01
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| Series: | Journal of Bahria University Medical and Dental College |
| Subjects: | |
| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/337 |
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| author | Mehtab Munir Khalid Mustafa Memon M Sajid Abbas Jaffri |
| author_facet | Mehtab Munir Khalid Mustafa Memon M Sajid Abbas Jaffri |
| author_sort | Mehtab Munir |
| collection | DOAJ |
| description |
Osteoarthritis, an inflammatory, degenerative disease of joints mostly affects weight bearing joints in old age. Treatment
modalities are categorized into non-pharmacological, pharmacological and surgical. Among pharmacological options, oral
formulations are mostly used. Acetaminophen is considered as first line though, NSAIDs are well established choice for
the management of osteoarthritis and mostly employed for the same. However NSAIDs are associated with gastric adverse
effects. Symptomatic slow acting osteoarthritis drugs like glucosamine, chondroitin sulfate, diacerein and avocado soybean
saponifiables are considered as maintenance therapy as they have shown to reserve joint space width. Topical formulations
are good for patients with co-morbidities. For patient not responding to other modalities, opioids and duloxetine are
employed but with caution. Intra-articular injections like corticosteroids, hyaluronic acid and Platelet rich plasma are ranked
highest in efficacy. Newer agents like Nerve growth factor- inhibitors, Interleukin-1 antagonists and certain neutraceutical
preparations are under investigation for osteoarthritis management.
|
| format | Article |
| id | doaj-art-88ef96cc7e5f4a5a893d61986cc36bd9 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-88ef96cc7e5f4a5a893d61986cc36bd92025-08-20T03:13:08ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822019-03-019110.51985/JBUMDC2018084Pharmacological Treatment Of Osteoarthritis In A NutshellMehtab MunirKhalid Mustafa MemonM Sajid Abbas Jaffri Osteoarthritis, an inflammatory, degenerative disease of joints mostly affects weight bearing joints in old age. Treatment modalities are categorized into non-pharmacological, pharmacological and surgical. Among pharmacological options, oral formulations are mostly used. Acetaminophen is considered as first line though, NSAIDs are well established choice for the management of osteoarthritis and mostly employed for the same. However NSAIDs are associated with gastric adverse effects. Symptomatic slow acting osteoarthritis drugs like glucosamine, chondroitin sulfate, diacerein and avocado soybean saponifiables are considered as maintenance therapy as they have shown to reserve joint space width. Topical formulations are good for patients with co-morbidities. For patient not responding to other modalities, opioids and duloxetine are employed but with caution. Intra-articular injections like corticosteroids, hyaluronic acid and Platelet rich plasma are ranked highest in efficacy. Newer agents like Nerve growth factor- inhibitors, Interleukin-1 antagonists and certain neutraceutical preparations are under investigation for osteoarthritis management. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/337osteoarthritis, treatment, pharmacological modalities, conservative |
| spellingShingle | Mehtab Munir Khalid Mustafa Memon M Sajid Abbas Jaffri Pharmacological Treatment Of Osteoarthritis In A Nutshell Journal of Bahria University Medical and Dental College osteoarthritis, treatment, pharmacological modalities, conservative |
| title | Pharmacological Treatment Of Osteoarthritis In A Nutshell |
| title_full | Pharmacological Treatment Of Osteoarthritis In A Nutshell |
| title_fullStr | Pharmacological Treatment Of Osteoarthritis In A Nutshell |
| title_full_unstemmed | Pharmacological Treatment Of Osteoarthritis In A Nutshell |
| title_short | Pharmacological Treatment Of Osteoarthritis In A Nutshell |
| title_sort | pharmacological treatment of osteoarthritis in a nutshell |
| topic | osteoarthritis, treatment, pharmacological modalities, conservative |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/337 |
| work_keys_str_mv | AT mehtabmunir pharmacologicaltreatmentofosteoarthritisinanutshell AT khalidmustafamemon pharmacologicaltreatmentofosteoarthritisinanutshell AT msajidabbasjaffri pharmacologicaltreatmentofosteoarthritisinanutshell |