Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives
The rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures. This review focuses on quinazoline derivatives synthesis and antimicrobial activity, high...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006519 |
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| author | Vishwanath Halappanavar Sangappa Teli Hanamant B. Sannakki Dharyappa Teli |
| author_facet | Vishwanath Halappanavar Sangappa Teli Hanamant B. Sannakki Dharyappa Teli |
| author_sort | Vishwanath Halappanavar |
| collection | DOAJ |
| description | The rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures. This review focuses on quinazoline derivatives synthesis and antimicrobial activity, highlighting their potential as antimicrobial agents. Synthetic methods include transition metal-mediated reactions, microwave-assisted techniques, and Aza reactions. The review critically evaluates the efficacy of quinazoline derivatives against drug-resistant pathogens and explores avenues for developing quinazoline-based antimicrobials. Recent advances in antimicrobial activity are also discussed. With their natural accomplishments, quinazoline derivatives have the potential to advance the development of novel antibiotics and fill the gap for potent antimicrobial drugs. Medicinal chemistry researchers seeking novel antimicrobial agents will find this evaluation valuable. |
| format | Article |
| id | doaj-art-88ee180e62a3421f9f9ce18bcaa5bbe8 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-88ee180e62a3421f9f9ce18bcaa5bbe82025-01-29T05:00:41ZengElsevierResults in Chemistry2211-71562025-01-0113101955Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivativesVishwanath Halappanavar0Sangappa Teli1Hanamant B. Sannakki2Dharyappa Teli3Department of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapura 586103, Karnataka, IndiaCorresponding author.; Department of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapura 586103, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapura 586103, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapura 586103, Karnataka, IndiaThe rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures. This review focuses on quinazoline derivatives synthesis and antimicrobial activity, highlighting their potential as antimicrobial agents. Synthetic methods include transition metal-mediated reactions, microwave-assisted techniques, and Aza reactions. The review critically evaluates the efficacy of quinazoline derivatives against drug-resistant pathogens and explores avenues for developing quinazoline-based antimicrobials. Recent advances in antimicrobial activity are also discussed. With their natural accomplishments, quinazoline derivatives have the potential to advance the development of novel antibiotics and fill the gap for potent antimicrobial drugs. Medicinal chemistry researchers seeking novel antimicrobial agents will find this evaluation valuable.http://www.sciencedirect.com/science/article/pii/S2211715624006519Drug-resistant pathogens4(3)-Quinazoline-one derivativesAntimicrobial activityChemical reactionsSynthetic methods |
| spellingShingle | Vishwanath Halappanavar Sangappa Teli Hanamant B. Sannakki Dharyappa Teli Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives Results in Chemistry Drug-resistant pathogens 4(3)-Quinazoline-one derivatives Antimicrobial activity Chemical reactions Synthetic methods |
| title | Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives |
| title_full | Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives |
| title_fullStr | Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives |
| title_full_unstemmed | Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives |
| title_short | Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives |
| title_sort | quinazoline scaffold as a target for combating microbial resistance synthesis and antimicrobial profiling of quinazoline derivatives |
| topic | Drug-resistant pathogens 4(3)-Quinazoline-one derivatives Antimicrobial activity Chemical reactions Synthetic methods |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006519 |
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