IMMUNOTHERAPY FOR MELANOMA
Melanoma is one of the most dangerous forms of skin cancer. Aggressive growth with a high risk of distant metastasis is the cause of the high death rate from skin melanoma worldwide. Melanoma that has metastasized beyond the lymph nodes requires more aggressive treatment. The standard treatment moda...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2017-09-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/571 |
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| _version_ | 1849253164550717440 |
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| author | E. A. Borobova A. A. Zheravin |
| author_facet | E. A. Borobova A. A. Zheravin |
| author_sort | E. A. Borobova |
| collection | DOAJ |
| description | Melanoma is one of the most dangerous forms of skin cancer. Aggressive growth with a high risk of distant metastasis is the cause of the high death rate from skin melanoma worldwide. Melanoma that has metastasized beyond the lymph nodes requires more aggressive treatment. The standard treatment modalities including surgery, radiation therapy and chemotherapy are not very effective for most patients. The aggressive nature of this disease sustains an urgent need for more effective treatment methods. Immunotherapy is currently one of the most promising approaches for fighting cancer cells. The review analyses the main immunotherapeutic approaches to melanoma treatment, including therapeutic vaccines based on tumor cells, synthetic peptides and polyepitopic immunogens. Many of these vaccines are currently being studied in various clinical trials. |
| format | Article |
| id | doaj-art-88ebd85e34ea431498f3e13162e53896 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-88ebd85e34ea431498f3e13162e538962025-08-20T03:56:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-09-01164657510.21294/1814-4861-2017-16-4-65-75469IMMUNOTHERAPY FOR MELANOMAE. A. Borobova0A. A. Zheravin1E.N. Meshalkin Siberian Biomedical Research Center; State Research Center of Virology and Biotechnology «VECTOR».E.N. Meshalkin Siberian Biomedical Research Center.Melanoma is one of the most dangerous forms of skin cancer. Aggressive growth with a high risk of distant metastasis is the cause of the high death rate from skin melanoma worldwide. Melanoma that has metastasized beyond the lymph nodes requires more aggressive treatment. The standard treatment modalities including surgery, radiation therapy and chemotherapy are not very effective for most patients. The aggressive nature of this disease sustains an urgent need for more effective treatment methods. Immunotherapy is currently one of the most promising approaches for fighting cancer cells. The review analyses the main immunotherapeutic approaches to melanoma treatment, including therapeutic vaccines based on tumor cells, synthetic peptides and polyepitopic immunogens. Many of these vaccines are currently being studied in various clinical trials.https://www.siboncoj.ru/jour/article/view/571melanomaimmunotherapyantigenscell vaccinespeptide vaccinesdna-vaccinesdendritic cells |
| spellingShingle | E. A. Borobova A. A. Zheravin IMMUNOTHERAPY FOR MELANOMA Сибирский онкологический журнал melanoma immunotherapy antigens cell vaccines peptide vaccines dna-vaccines dendritic cells |
| title | IMMUNOTHERAPY FOR MELANOMA |
| title_full | IMMUNOTHERAPY FOR MELANOMA |
| title_fullStr | IMMUNOTHERAPY FOR MELANOMA |
| title_full_unstemmed | IMMUNOTHERAPY FOR MELANOMA |
| title_short | IMMUNOTHERAPY FOR MELANOMA |
| title_sort | immunotherapy for melanoma |
| topic | melanoma immunotherapy antigens cell vaccines peptide vaccines dna-vaccines dendritic cells |
| url | https://www.siboncoj.ru/jour/article/view/571 |
| work_keys_str_mv | AT eaborobova immunotherapyformelanoma AT aazheravin immunotherapyformelanoma |