Stress-induced GHS-R1a expression in medial prefrontal cortical neurons promotes vulnerability to anxiety in mice

Stress-induced GHS-R1a expression in medial prefrontal cortical neurons promotes vulnerability to anxiety in mice

Abstract The neural basis of anxiety is unclear, which hinders the treatment of anxiety disorders. Here, we found that αCaMKII+ neurons in the medial prefrontal cortex (mPFCαCaMKII+) responded to stressors with increased activity both under physiological conditions and after repeated restraint stres...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu Yang, Meng Zhang, Xiaomin Sun, Anqi Du, Jiajia Jia, Nan Li, Gonghui Hu, Yingchang Lu, Sihan Wang, Jingsai Zhang, Wenjie Chen, Hanbing Yu, Yu Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07802-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items