Short-term high-fat diet impacts bone material properties and metabolism for adult and aged C57BL/6JN mice

Abstract The elderly are at increased risk of bone fracture and more often consume poor quality diets, such as high-fat diet (HFD). We hypothesized that HFD exacerbates the loss of bone fracture resistance in aging. Female and male 5-month and 22-month C57BL/6JN mice were fed moderate HFD (45%) or l...

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Main Authors: Kenna Brown, Ghazal Vahidi, Brady D. Hislop, Maya Moody, Steven Watson, Hope D. Welhaven, Ramina Behzad, Kat O. Paton, Lamya Karim, Ronald K. June, Stephen A. Martin, Chelsea M. Heveran
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08263-w
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